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BioMed Research International
Volume 2015 (2015), Article ID 247469, 11 pages
http://dx.doi.org/10.1155/2015/247469
Research Article

The Role of Fundus Autofluorescence Imaging in the Study of the Course of Posterior Uveitis Disorders

1Department of Ophthalmology, Ocular Immunology and Inflammation Service, “G. Gennimatas” General Hospital of Athens, Athens, Greece
21st Department of Ophthalmology, “G. Gennimatas” General Hospital of Athens, University of Athens, 59 Chrysnathemon Street, Psychiko, 15452 Athens, Greece
3Institute of Ocular Inflammation and Pathology of the Eye, Athens, Greece

Received 29 July 2014; Accepted 29 October 2014

Academic Editor: Timothy Y. Lai

Copyright © 2015 Panagiotis Malamos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. Methods. Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis. Also, some cases with undefined retinochoroiditis were included. FAF and ICGA were performed and correlated at baseline and during follow-up after treatment. Results. In ICGA, early hypofluorescence was found to be the hallmark of acute choroidal inflammation, resolving in later stages and remaining in the late phase in areas with retinal pigment epithelium (RPE) damage. Poorly defined hyperautofluorescent areas correlated with acute choroidal lesions. Hypoautofluorescent delineation suggested the initiation of RPE healing processes, correlating well with the late phase of ICGA and delineating the RPE damage. Early hyperautofluorescence with late hypofluorescence in ICGA indicated the presence of primary RPE involvement. Conclusion. FAF contributes to the interpretation of RPE disease and may be a useful tool for the follow-up of progressive inflammatory disorders. Comparative evaluation of FAF and ICGA allows a characterization of the sequence of inflammatory events and the level of tissue affected.