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BioMed Research International
Volume 2015 (2015), Article ID 294024, 8 pages
http://dx.doi.org/10.1155/2015/294024
Research Article

Measurement of Liver Iron Concentration by MRI Is Reproducible

1Osatek, Donostia Universitary Hospital, P. Dr. Beguiristain 109, 20014 Donostia/San Sebastián, Spain
2Clinical Epidemiology, Donostia Universitary Hospital, P. Dr. Beguiristain 117, 20080 Donostia/San Sebastián, Spain
3Gastroenterology, Mendaro Hospital, Mendarozabal s/n, Mendaro, Spain
4Basque Country University, Avenida Tolosa 54, 20018 Donostia/San Sebastián, Spain
5Biochemical Laboratory, Donostia Universitary Hospital, P. Dr. Beguiristain 117, 20080 Donostia/San Sebastián, Spain
6Experimental Department, Donostia Universitary Hospital, P. Dr. Beguiristain 117, 20080 Donostia/San Sebastián, Spain
7Liver Diseases Unit, Biodonostia Research Institute, P. Dr. Beguiristain s/n, 20014 Donostia/San Sebastián, Spain
8Policlínica Gipúzkoa, Paseo Miramón 174, 20014 Donostia/San Sebastián, Spain
9Radiology, Quirón Donostia Hospital, Alkolea Parkea 7, 20012 Donostia/San Sebastián, Spain
10Onkologikoa, P. Dr. Beguiristain s/n, 20011 Donostia/San Sebastián, Spain

Received 22 May 2014; Accepted 14 September 2014

Academic Editor: Pascal Niggemann

Copyright © 2015 José María Alústiza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. Materials and Methods. A phantom reproducing the liver/muscle ratios of two patients with intermediate and high iron overload. Nine patients with different levels of iron overload were studied in 4 multivendor devices and 8 of them were studied twice in the machine where the model was developed. The phantom was analysed in the same equipment and 14 times in the reference machine. Results. FeCl3 solutions containing 0.3, 0.5, 0.6, and 1.2 mg Fe/mL were chosen to generate the phantom. The average of the intramachine variability for patients was 10% and for the intermachines 8%. For the phantom the intramachine coefficient of variation was always below 0.1 and the average of intermachine variability was 10% for moderate and 5% for high iron overload. Conclusion. The phantom reproduces the behavior of patients with moderate or high iron overload. The proposed method of calculating liver iron concentration is reproducible in several different 1.5 T systems.