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BioMed Research International
Volume 2015, Article ID 294954, 8 pages
http://dx.doi.org/10.1155/2015/294954
Review Article

Circulating MicroRNAs as Clinical Biomarkers in the Predictions of Pregnancy Complications

1Assistance Publique-Hôpitaux de Marseille, Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Fœtale, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France
2Assistance Publique-Hôpitaux de Marseille, Centre Pluridisciplinaire de Diagnostic Prénatal, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France

Received 11 July 2014; Revised 30 September 2014; Accepted 7 October 2014

Academic Editor: Nadia Alfaidy

Copyright © 2015 Marthe Tsochandaridis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Predicting pregnancy complications is a major topic for clinicians and biologists for maternal and fetal monitoring. Noninvasive biomarkers in maternal blood such as circulating microRNAs (miRNAs) are promising molecules to predict pregnancy disorders. miRNAs are noncoding short RNAs that regulate mRNA expression by repressing the translation or cleaving the transcript. miRNAs are released to the extracellular systemic circulation via exosomes. The discovery of plasma- or serum-derived miRNAs and of free-circulating exosomes that contain miRNAs provides useful information about the physiological or pathophysiological roles of the miRNAs. Specific placental miRNAs are present in maternal plasma in different ways depending on whether the pregnancy is normal or pathological or if there is no pregnancy. This paper focuses on placental miRNAs and extracellular miRNAs to the placenta whose misregulation could lead to pregnancy complications.