BioMed Research International

BioMed Research International / 2015 / Article
Special Issue

Helicobacter pylori and Pathogenesis

View this Special Issue

Letter to the Editor | Open Access

Volume 2015 |Article ID 354519 |

Amin Talebi Bezmin Abadi, Enzo Ierardi, "Comment on “Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling”", BioMed Research International, vol. 2015, Article ID 354519, 2 pages, 2015.

Comment on “Helicobacter pylori Outer Membrane Protein 18 (Hp1125) Is Involved in Persistent Colonization by Evading Interferon-γ Signaling”

Academic Editor: Hidekazu Suzuki
Received12 Nov 2014
Accepted27 Nov 2014
Published06 Apr 2015

We read with interest the paper by Shan et al. [1] in a recent issue. It is an interesting paper concluding that Helicobacter pylori (H. pylori) omp18 is indirectly affecting long term bacterial colonization by successfully influencing IFN-γ-mediated immune response. Nevertheless, we found that some statements could not support the final conclusion. H. pylori infects the gastric mucosal layer of half of the human population worldwide and causes various digestive disorders such as chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer [2]. To date, it has been established that such complex mechanism of bacterial interaction with human host can shape the successful and persistent colonization of H. pylori [3, 4]. Undoubtedly, understanding the mechanisms of immune evasion could provide new options for better management of infection. To our knowledge, the host immune response to the infection is ineffective; accordingly, the bacterium persists and remains for decades. In brief, Shan et al. [1] reported the oipA as a critical factor affecting bacterial colonization. However, we know that, in chronic process of colonization adopted by H. pylori, the connection of a unique factor to the drive of the final pattern of this phenomenon could be too speculative. Despite the interesting report of Shan et al. [1], we may hypothesize more factors involved in H. pylori colonization. Surprisingly, H. pylori colonization is not comparable with that of other pathogens [5]. Indeed, different mechanisms are contributing to this mysterious and long term biologic function. Conclusively, more studies are necessary to draw a direct and final conclusion on “the mystery” of H. pylori colonization.


The contents of the paper are the sole responsibility of the authors and do not necessarily represent the official views of any institute or organization.

Conflict of Interests

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interests.


  1. Y. Shan, X. Lu, Y. Han et al., “Helicobacter pylori outer membrane protein 18 (Hp1125) is involved in persistent colonization by evading interferon-γ signaling,” BioMed Research International, vol. 2014, Article ID 571280, 12 pages, 2014. View at: Publisher Site | Google Scholar
  2. A. Sheh and J. G. Fox, “The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis,” Gut Microbes, vol. 4, no. 6, pp. 505–531, 2013. View at: Publisher Site | Google Scholar
  3. A. T. B. Abadi, “Helicobacter pylori: a beneficial gastric pathogen?” Gastroenterology, vol. 1, article 26, 2014. View at: Google Scholar
  4. A. T. B. Abadi, “Therapy of helicobacter pylori: present medley and future prospective,” BioMed Research International, vol. 2014, Article ID 124607, 7 pages, 2014. View at: Publisher Site | Google Scholar
  5. R. Bücker, M. Azevedo-Vethacke, C. Groll et al., “Helicobacter pylori colonization critically depends on postprandial gastric conditions,” Scientific Reports, vol. 2, article 994, 2012. View at: Publisher Site | Google Scholar

Copyright © 2015 Amin Talebi Bezmin Abadi and Enzo Ierardi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.