Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 362542, 9 pages
http://dx.doi.org/10.1155/2015/362542
Research Article

Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility

1The State Key Lab of Respiratory Disease, Collaborative Innovation Center for Environmental Toxicity, The Institute for Chemical Carcinogenesis, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou 510182, China
2Department of Genetics, Collaborative Innovation Center for Environmental Toxicity, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, China

Received 5 June 2014; Revised 23 September 2014; Accepted 23 September 2014

Academic Editor: Yung-Fu Chang

Copyright © 2015 Yehua Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-P. Liu, L. Cassar, A. Pinto, and H. Li, “Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma,” Cell Research, vol. 16, no. 10, pp. 809–817, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. W.-H. Jia, Q.-H. Huang, J. Liao et al., “Trends in incidence and mortality of nasopharyngeal carcinoma over a 20–25 year period (1978/1983–2002) in Sihui and Cangwu counties in Southern China,” BMC Cancer, vol. 6, article 178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. C. Yu and J.-M. Yuan, “Epidemiology of nasopharyngeal carcinoma,” Seminars in Cancer Biology, vol. 12, no. 6, pp. 421–429, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. E. T. Chang and H.-O. Adami, “The enigmatic epidemiology of nasopharyngeal carcinoma,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 10, pp. 1765–1777, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. A. Vasef, A. Ferlito, and L. M. Weiss, “Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus,” Annals of Otology, Rhinology and Laryngology, vol. 106, no. 4, pp. 348–356, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. R. W. Armstrong, P. B. Imrey, M. S. Lye, M. J. Armstrong, M. C. Yu, and S. Sani, “Nasopharyngeal carcinoma in Malaysian Chinese: salted fish and other dietary exposures,” International Journal of Cancer, vol. 77, no. 2, pp. 228–235, 1998. View at Publisher · View at Google Scholar
  8. X. Ji, W. Zhang, C. Xie, B. Wang, G. Zhang, and F. Zhou, “Nasopharyngeal carcinoma risk by histologic type in central China: impact of smoking, alcohol and family history,” International Journal of Cancer, vol. 129, no. 3, pp. 724–732, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Zheng, L. L. Li, D. S. Hu, X. Y. Deng, and Y. Cao, “Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma,” Cellular & Molecular Immunology, vol. 4, no. 3, pp. 185–196, 2007. View at Google Scholar · View at Scopus
  10. J. L. Arbiser, “Implications of Epstein-Barr Virus (EBV)-induced carcinogenesis on cutaneous inflammation and carcinogenesis: evidence of recurring patterns of angiogenesis and signal transduction,” Journal of Investigative Dermatology, vol. 124, no. 5, pp. xi–xii, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. F. R. Greten, L. Eckmann, T. F. Greten et al., “IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer,” Cell, vol. 118, no. 3, pp. 285–296, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Pikarsky, R. M. Porat, I. Stein et al., “NF-κB functions as a tumour promoter in inflammation-associated cancer,” Nature, vol. 431, no. 7007, pp. 461–466, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Karin, “Nuclear factor-κB in cancer development and progression,” Nature, vol. 441, no. 7092, pp. 431–436, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Karin, “NF-kappaB as a critical link between inflammation and cancer,” Cold Spring Harbor Perspectives in Biology, vol. 1, no. 5, Article ID a000141, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. B. B. Aggarwal, Y. Takada, S. Shishodia et al., “Nuclear transcription factor NF-kappa B: role in biology and medicine,” Indian Journal of Experimental Biology, vol. 42, no. 4, pp. 341–353, 2004. View at Google Scholar · View at Scopus
  16. M. M. Chaturvedi, B. Sung, V. R. Yadav, R. Kannappan, and B. B. Aggarwal, “NF-κB addiction and its role in cancer: one size does not fit all,” Oncogene, vol. 30, no. 14, pp. 1615–1630, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Karin and F. R. Greten, “NF-κB: linking inflammation and immunity to cancer development and progression,” Nature Reviews Immunology, vol. 5, no. 10, pp. 749–759, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Chen, V. Castranova, X. Shi, and L. M. Demers, “New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases,” Clinical Chemistry, vol. 45, no. 1, pp. 7–17, 1999. View at Google Scholar · View at Scopus
  19. M. S. Hayden, A. P. West, and S. Ghosh, “SnapShot: NF-κB signaling pathways,” Cell, vol. 127, no. 6, pp. 1286.e1–1286.e2, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. A. S. Karban, T. Okazaki, C. I. M. Panhuysen et al., “Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis,” Human Molecular Genetics, vol. 13, no. 1, pp. 35–45, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. He, H. Zhang, J. Yin et al., “IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C,” Carcinogenesis, vol. 30, no. 11, pp. 1916–1922, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Song, D. Chen, J. Lu et al., “NFkappaB1 and NFkappaBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population,” PLoS ONE, vol. 6, no. 6, Article ID e21726, 2011. View at Google Scholar
  23. D. Huang, L. Yang, Y. Liu et al., “Functional polymorphisms in NFκB1/IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese,” Human Genetics, vol. 132, no. 4, pp. 451–460, 2013. View at Publisher · View at Google Scholar
  24. L. Yang, B. Liu, F. Qiu et al., “The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection,” Carcinogenesis, vol. 35, no. 1, pp. 46–52, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Lu, L. Yang, H. Zhao et al., “The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in southern and eastern chinese populations,” Human Mutation, vol. 32, no. 11, pp. 1299–1308, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Liu, D. Chen, L. Yang et al., “A functional variant (−1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity,” Carcinogenesis, vol. 31, no. 8, pp. 1405–1411, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Yang, Y. Li, M. Cheng et al., “A functional polymorphism at microRNA-629-binding site in the 3′-untranslated region of nbs1 gene confers an increased risk of lung cancer in southern and eastern chinese population,” Carcinogenesis, vol. 33, no. 2, pp. 338–347, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. V. Sampath, M. Le, L. Lane et al., “The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants,” Journal of Surgical Research, vol. 169, no. 1, pp. e51–e57, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Marcos, I. Pastor, R. González-Sarmiento, and F. J. Laso, “A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence,” Alcoholism: Clinical and Experimental Research, vol. 33, no. 11, pp. 1857–1862, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. H. Hung, C. C. Wu, and T. T. Ou, “IκBα promoter polymorphisms in patients with Behçet’s disease,” Disease Markers, vol. 28, no. 1, pp. 55–62, 2010. View at Publisher · View at Google Scholar
  31. P. Zhang, Q. Wei, X. Li et al., “A functional insertion/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer,” Cancer Genetics and Cytogenetics, vol. 191, no. 2, pp. 73–77, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. W. D. Dupont and W. D. Plummer Jr., “Power and sample size calculations. A review and computer program,” Controlled Clinical Trials, vol. 11, no. 2, pp. 116–128, 1990. View at Publisher · View at Google Scholar · View at Scopus
  33. L. L. Yates and D. C. Górecki, “The nuclear factor-kappaB (NF-κB): from a versatile transcription factor to a ubiquitous therapeutic target,” Acta Biochimica Polonica, vol. 53, no. 4, pp. 651–662, 2006. View at Google Scholar · View at Scopus
  34. R. O. Escarcega, “The transcription factor NF-κB in human diseases,” Revista Médica del Instituto Mexicano del Seguro Social, vol. 48, no. 1, pp. 55–60, 2010. View at Google Scholar
  35. C.-C. Chen, H.-P. Liu, M. Chao et al., “NF-κB-mediated transcriptional upregulation of TNFAIP2 by the Epstein-Barr virus oncoprotein, LMP1, promotes cell motility in nasopharyngeal carcinoma,” Oncogene, vol. 33, pp. 3648–3659, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. H. J. Kim, K. W. Kim, B. P. Yu, and H. Y. Chung, “The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation,” Free Radical Biology & Medicine, vol. 28, no. 5, pp. 683–692, 2000. View at Google Scholar
  37. H. Abe, C. N. Hayes, H. Ochi et al., “Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state,” Journal of Medical Virology, vol. 83, no. 9, pp. 1597–1607, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Riemann, L. Becker, H. Struwe, H. Rübben, A. Eisenhardt, and W. Siffert, “Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer,” International Journal of Clinical Pharmacology and Therapeutics, vol. 45, no. 8, pp. 423–430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Gao, D. Pfeifer, L.-J. He et al., “Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations,” Scandinavian Journal of Gastroenterology, vol. 42, no. 3, pp. 345–350, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. D. Huang, L. Yang, Y. Liu et al., “Functional polymorphisms in NFκB1/IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese,” Human Genetics, vol. 132, no. 4, pp. 451–460, 2013. View at Publisher · View at Google Scholar
  41. P. Li, J. Gu, X. Yang et al., “Functional promoter-94 ins/del ATTG polymorphism in NFKB1 gene is associated with bladder cancer risk in a Chinese population,” PLoS ONE, vol. 8, no. 8, Article ID e71604, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Arisawa, T. Tahara, H. Shiroeda et al., “Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer,” Oncology Reports, vol. 30, no. 6, pp. 3013–3019, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. Z. Yu, Z. Li, N. Jolicoeur et al., “Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers,” Nucleic Acids Research, vol. 35, no. 13, pp. 4535–4541, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Wacholder, S. Chanock, M. Garcia-Closas, L. El Ghormli, and N. Rothman, “Assessing the probability that a positive report is false: an approach for molecular epidemiology studies,” Journal of the National Cancer Institute, vol. 96, no. 6, pp. 434–442, 2004. View at Publisher · View at Google Scholar · View at Scopus