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BioMed Research International
Volume 2015, Article ID 362542, 9 pages
Research Article

Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility

1The State Key Lab of Respiratory Disease, Collaborative Innovation Center for Environmental Toxicity, The Institute for Chemical Carcinogenesis, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou 510182, China
2Department of Genetics, Collaborative Innovation Center for Environmental Toxicity, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, China

Received 5 June 2014; Revised 23 September 2014; Accepted 23 September 2014

Academic Editor: Yung-Fu Chang

Copyright © 2015 Yehua Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. Genotyping results of the selected SNPs in the NFκB and IκBα genes. (A). Genotyping of rs28362491del>ins ATTG in NFκB1, rs12769316G>A in NFκB2, rs2233406C>T and rs696G>A in IκBα detected by the TaqMan allelic discrimination assay. (B). The genotypes of the four SNPs were validated by direct sequencing and the results were all 100% concordant. Table S1. Primary information on the TaqMan assay of four SNPs in the NFκB and IκBα genes. Table S2. Frequency distributions of selected variables in NPC patients and controls. Briefly, only the factors including smoking, drinking status, and EBV status had significant different between cases and controls in the two study populations.

  1. Supplementary Material