Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015 (2015), Article ID 373252, 5 pages
http://dx.doi.org/10.1155/2015/373252
Research Article

A Functional Variant at miR-520a Binding Site in PIK3CA Alters Susceptibility to Colorectal Cancer in a Chinese Han Population

1Department of Oncology, Danyang People’s Hospital, Danyang 213000, China
2Department of Oncology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China
3Department of Central Laboratory, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, China
4Department of Oncology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, China
5Department of Clinical Laboratory, Taixing People’s Hospital, Taixing 225400, China

Received 25 June 2014; Accepted 12 January 2015

Academic Editor: Pedro Moral

Copyright © 2015 Lifang Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Zhao, M. Dai, W. Chen, and N. Li, “Cancer trends in China,” Japanese Journal of Clinical Oncology, vol. 40, no. 4, pp. 281–285, 2010. View at Publisher · View at Google Scholar
  3. M. J. Arends, “Pathways of colorectal carcinogenesis,” Applied Immunohistochemistry and Molecular Morphology, vol. 21, no. 2, pp. 97–102, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Tannapfel, M. Neid, D. Aust, and G. Baretton, “The origins of colorectal carcinoma: specific nomenclature for different pathways and precursor lesions,” Deutsches Ärzteblatt International, vol. 107, no. 43, pp. 760–766, 2010. View at Publisher · View at Google Scholar
  5. Z.-B. Ma, K. Li, J. Wang, and G.-H. Guo, “Role of KAI1/CD82 polymorphisms in colon cancer risk in Han Chinese population,” Medical Oncology, vol. 30, no. 3, article 668, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. J. J. Hu, H. W. Mohrenweiser, D. A. Bell, S. A. Leadon, and M. S. Miller, “Symposium overview: genetic polymorphisms in DNA repair and cancer risk,” Toxicology and Applied Pharmacology, vol. 185, no. 1, pp. 64–73, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. T.-Y. Shi, X.-J. Chen, M.-L. Zhu et al., “A pri-miR-218 variant and risk of cervical carcinoma in Chinese women,” BMC Cancer, vol. 13, article 19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Cathomas, “PIK3CA in colorectal cancer,” Frontiers in Oncology, vol. 4, article 35, 2014. View at Publisher · View at Google Scholar
  9. R. Garg, V. Kapoor, M. Mittal, M. K. Singh, N. K. Shukla, and S. N. Das, “Abnormal expression of PI3K isoforms in patients with tobacco-related oral squamous cell carcinoma,” Clinica Chimica Acta, vol. 416, pp. 100–106, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. W. C. S. Cho, “MicroRNAs in cancer—from research to therapy,” Biochimica et Biophysica Acta, vol. 1805, no. 2, pp. 209–217, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. C. S. Cho, “MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy,” International Journal of Biochemistry and Cell Biology, vol. 42, no. 8, pp. 1273–1281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Wang, L. Long, T. Li et al., “Polymorphisms of microRNA-binding sites in integrin genes are associated with oral squamous cell carcinoma susceptibility and progression,” Tohoku Journal of Experimental Medicine, vol. 233, no. 1, pp. 33–41, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Liu, S. Wei, H. Ma et al., “A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck,” Carcinogenesis, vol. 32, no. 11, pp. 1668–1674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Hikami, A. Kawasaki, I. Ito et al., “Association of a functional polymorphism in the 3′-untranslated region of SPI1 with systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 63, no. 3, pp. 755–763, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Wynendaele, A. Böhnke, E. Leucci et al., “An illegitimate microRNA target site within the 3′-UTR of MDM4 affects ovarian cancer progression and chemosensitivity,” Cancer Research, vol. 70, no. 23, pp. 9641–9649, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Zhang, Y. Liu, F. Song et al., “Functional SNP in the microRNA-367 binding site in the 3′-UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 33, pp. 13653–13658, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Miled, Y. Yan, W.-C. Hon et al., “Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit,” Science, vol. 317, no. 5835, pp. 239–242, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. G. Bader, S. Kang, and P. K. Vogt, “Cancer-specific mutations in PIK3CA are oncogenic in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 5, pp. 1475–1479, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Rosty, J. P. Young, M. D. Walsh et al., “PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival,” PLoS ONE, vol. 8, no. 6, Article ID e65479, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. F. B. Furnari, H.-J. Su Huang, and W. K. Cavenee, “The phosphoinositol phosphatase activity of PTEN mediates a serum- sensitive G1 growth arrest in glioma cells,” Cancer Research, vol. 58, no. 22, pp. 5002–5008, 1998. View at Google Scholar · View at Scopus
  21. E. Jabbour, O. G. Ottmann, M. Deininger, and A. Hochhaus, “Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies,” Haematologica, vol. 99, no. 1, pp. 7–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Samuels, Z. Wang, A. Bardelli et al., “High frequency of mutations of the PIK3CA gene in human cancers,” Science, vol. 304, no. 5670, p. 554, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. I. G. Campbell, S. E. Russell, D. Y. H. Choong et al., “Mutation of the PIK3CA gene in ovarian and breast cancer,” Cancer Research, vol. 64, no. 21, pp. 7678–7681, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M.-L. He, Y. Wu, J.-M. Zhao, Z. Wang, and Y.-B. Chen, “PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population,” Asian Pacific Journal of Cancer Prevention, vol. 14, no. 9, pp. 5117–5122, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Kommineni, K. Jamil, U. R. Pingali, L. Addala, and M. Naidu, “Association of PIK3CA gene mutations with head and neck squamous cell carcinomas,” Neoplasma, vol. 62, no. 1, pp. 72–80, 2015. View at Google Scholar