BioMed Research International

Biomedical Insights of Human Genetic Diversity in Complex Diseases


Publishing date
12 Dec 2014
Status
Published
Submission deadline
25 Jul 2014

1Department of Animal Biology, Section of Anthropology, Faculty of Biology, University of Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain

2Department of Life and Environmental Sciences, Section of Anthropological Sciences, University of Cagliari, Cittadella Universitaria, SS 554 (km 4,5), 09042 Monserrato, Cagliari, Italy

3National Institute of Biomedical Genomics, Netaji Subhas Sanatorium (T.B. Hospital), 2nd Floor, P.O.: N.S.S., Kalyani, West Bengal 741251, India


Biomedical Insights of Human Genetic Diversity in Complex Diseases

Description

The genetics of human populations has been a crucial point in classic anthropology since the 20th century. A century after, some chapters of our biological history will be closed thanks to the knowledge of complete genomes. Now it is time to search for new questions, and through this special issue we would like to enhance those scientists that are working on the border of anthropology, recent molecular techniques, and ethnic disparities in health to show the results of their research in biomedicine, linking anthropology, human genetics, and epidemiology.

The description of complete genomes and gene clusters allows us to go more deeply into the genetic risk factors for complex diseases that are the extreme manifestation of a continuum of genetic, physiological, and environmental features. This topic is of high current interest because large-scale genomic association studies in complex diseases have reported different rates among ethnic groups. The rich and diverse genetic past of some populations joined to the demographic changes increasing life expectancy, lifestyle, and industrialization in emerging countries makes them strong candidates to develop epidemic proportions of some complex diseases. This issue would like to contribute to understanding how genetic diversity of ethnic groups could contribute to health disparities in complex diseases in which genetic susceptibility depends on this genetic diversity.

We take particular interest in manuscripts analysing risk alleles, new statistical methods, and reviews of independent studies in ethnic groups, paying attention not only to genetic ancestry and admixture but also to environmental differences and health disparities which are welcome. Potential topics include, but are not limited to:

  • Risk alleles and ethnic differences in multifactorial diseases such as cancer, cardiovascular disorders, diabetes, obesity, and mental disorders
  • Statistical methods to analyse risk scores for complex diseases and epidemiological data
  • New technologies in the study of complex diseases
  • Genetic diversity and epidemiology in emerging countries

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/genetics/bihg/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 974809
  • - Editorial

Biomedical Insights of Human Genetic Diversity in Complex Diseases

M. Esther Esteban | Analabha Basu | ... | Pedro Moral
  • Special Issue
  • - Volume 2015
  • - Article ID 490295
  • - Research Article

TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

Helena Canhão | Ana Maria Rodrigues | ... | Elizabeth W. Karlson
  • Special Issue
  • - Volume 2015
  • - Article ID 373252
  • - Research Article

A Functional Variant at miR-520a Binding Site in PIK3CA Alters Susceptibility to Colorectal Cancer in a Chinese Han Population

Lifang Ding | Zao Jiang | ... | Hao Li
  • Special Issue
  • - Volume 2015
  • - Article ID 718786
  • - Research Article

Novel Mutations in the Transcriptional Activator Domain of the Human TBX20 in Patients with Atrial Septal Defect

Irma Eloisa Monroy-Muñoz | Nonanzit Pérez-Hernández | ... | Gilberto Vargas-Alarcón
  • Special Issue
  • - Volume 2015
  • - Article ID 825468
  • - Research Article

Mosaicism of Mitochondrial Genetic Variation in Atherosclerotic Lesions of the Human Aorta

Margarita A. Sazonova | Vasily V. Sinyov | ... | Alexander N. Orekhov
  • Special Issue
  • - Volume 2014
  • - Article ID 769452
  • - Research Article

Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure

Chih-Chiang Wu | Chia-Yu Ou | ... | Kuender D. Yang
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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