Experimental Protoporphyria: Effect of Bile Acids on Liver Damage Induced by Griseofulvin

Figure 4

Effect of bile acid on MDA, GSH levels and liver antioxidant defense system. (a) MDA levels, mean control value: 7.94 ± 1.39 nmol/mg protein (). (b) GSH levels, mean control value: 27.05 ± 5.11 nmol/mg protein (). (c) GRed, mean control value: 40.11 ± 4.96 nmol/mg protein (); (d) SOD, mean control value: 71.95 ± 10.93 nmol/mg protein (). Results are expressed as percentage of the corresponding control value taken as 100%. and , significance of differences between the groups treated and the control group. and , significance of differences between the group treated with Gris plus bile acid with respect to that receiving only Gris. and , significance of differences between the group treated with Gris plus bile acid with respect to the group receiving only bile acid. More experimental details are described in legend of Figure 2.

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