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BioMed Research International
Volume 2015, Article ID 453543, 15 pages
http://dx.doi.org/10.1155/2015/453543
Review Article

Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA

Received 28 February 2014; Accepted 1 September 2014

Academic Editor: Anna Di Fiore

Copyright © 2015 Melissa A. Pinard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Surface rendition of carbonic anhydrase II showing how various inhibitors bind in and around the active site cleft. The “conserved region” (green) and “selective pocket” indicate regions of preferred binding by various carbonic anhydrase inhibitors.

  1. Supplementary Figure