BioMed Research International

Recent Developments of Carbonic Anhydrase Inhibitors as Potential Drugs


Publishing date
14 Nov 2014
Status
Published
Submission deadline
27 Jun 2014

Lead Editor

1Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan

2Department of Chemistry, Forman Christian College Ferozepur Road 54600, Lahore, Pakistan

3Division of Biophysics, Department of Basic Medical Sciences, Bahcesehir University School of Medicine, Istanbul, Turkey

4Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy


Recent Developments of Carbonic Anhydrase Inhibitors as Potential Drugs

Description

Carbonic anhydrases (CAs) are a group of zinc-containing metalloenzymes which are ubiquitous in nature. It is a physiologically important enzyme that is responsible for catalyzing the reversible hydration of carbon dioxide to bicarbonate with the release of protons. Overexpression of this enzyme has been implicated in many disorders such as glaucoma, obesity, gastric ulcers, acid-base imbalances, and epilepsy. Carbonic anhydrase, therefore, has emerged as a valuable drug target for treatment or prevention of these disorders. Many clinically established drugs are CA inhibitors, and it is highly anticipated that many more will eventually find their way into the market.

One of the greatest challenges in the design of CA inhibitors is their lack of selectivity against CA isozymes. There are 16 (currently known) isozymes of CA with different tissue distribution and subcellular localization. Discovery of cancer-associated isozymes of CA (CA IX and CA XII) has sparked a renewed interest in the design of novel scaffolds with selective inhibition against these transmembrane cancer-associated CA isozymes. Much development has been made in this field; however, in order to find isozyme selective inhibitors with increased CA inhibition activity, it is necessary that new classes of compounds should be screened on CA isozymes. Original research manuscripts that report advancement in the field are invited. Potential topics include, but are not limited to:

  • Discovery of new scaffolds with CA inhibition activity
  • Design of isozyme selective CA inhibitors
  • Targeted drug delivery systems for CA inhibitors
  • Fluorescent CA inhibitors for imaging of hypoxic tumors
  • Inhibition of bacterial (pathogenic) carbonic anhydrase
  • Quantitative structure activity relationship studies that identify new leads for design of more active or selective inhibitors

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http:///www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/rdc/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 174178
  • - Editorial

Recent Developments of Carbonic Anhydrase Inhibitors as Potential Drugs

Jamshed Iqbal | Mariya Al-Rashida | ... | Anna Di Fiore
  • Special Issue
  • - Volume 2015
  • - Article ID 453543
  • - Review Article

Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Melissa A. Pinard | Brian Mahon | Robert McKenna
  • Special Issue
  • - Volume 2015
  • - Article ID 674920
  • - Research Article

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

Emanuele Sasso | Monica Vitale | ... | Nicola Zambrano
  • Special Issue
  • - Volume 2014
  • - Article ID 389869
  • - Research Article

Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations

Pavel Mader | Adam Pecina | ... | Pavlína Řezáčová
  • Special Issue
  • - Volume 2014
  • - Article ID 162928
  • - Research Article

Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs

Mariya al-Rashida | Sajad Hussain | ... | Jamshed Iqbal
  • Special Issue
  • - Volume 2014
  • - Article ID 638902
  • - Research Article

Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

Vaida Morkūnaitė | Lina Baranauskienė | ... | Daumantas Matulis
  • Special Issue
  • - Volume 2014
  • - Article ID 523210
  • - Research Article

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

Giuseppina De Simone | Ginta Pizika | ... | Vincenzo Alterio
  • Special Issue
  • - Volume 2014
  • - Article ID 374079
  • - Research Article

Natural Product Polyamines That Inhibit Human Carbonic Anhydrases

Rohan A. Davis | Daniela Vullo | ... | Sally-Ann Poulsen
  • Special Issue
  • - Volume 2014
  • - Article ID 594879
  • - Research Article

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II

Hilal Kuday | Fatih Sonmez | ... | Mustafa Kucukislamoglu
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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