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BioMed Research International
Volume 2015, Article ID 459393, 11 pages
http://dx.doi.org/10.1155/2015/459393
Research Article

Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study

1Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea
2Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea
3Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Republic of Korea

Received 21 May 2015; Revised 14 July 2015; Accepted 15 July 2015

Academic Editor: Giuseppe Cama

Copyright © 2015 Nam-Ho Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Albrektsson, P.-I. Brånemark, H.-A. Hansson, and J. Lindström, “Osseointegrated titanium implants: requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man,” Acta Orthopaedica, vol. 52, no. 2, pp. 155–170, 1981. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Le Guéhennec, A. Soueidan, P. Layrolle, and Y. Amouriq, “Surface treatments of titanium dental implants for rapid osseointegration,” Dental Materials, vol. 23, no. 7, pp. 844–854, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. P.-I. Brånemark, U. Breine, R. Adell, B. O. Hansson, J. Lindström, and A. Ohlsson, “Intra-osseous anchorage of dental prostheses: I. Experimental studies,” Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, vol. 3, no. 2, pp. 81–100, 1969. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Mendonça, D. B. S. Mendonça, F. J. L. Aragão, and L. F. Cooper, “Advancing dental implant surface technology—from micron- to nanotopography,” Biomaterials, vol. 29, no. 28, pp. 3822–3835, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. von Wilmowsky, S. Bauer, R. Lutz et al., “In vivo evaluation of anodic TiO2 nanotubes: an experimental study in the pig,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 89, no. 1, pp. 165–171, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Ponader, C. Von Wilmowsky, M. Widenmayer et al., “In vivo performance of selective electron beam-melted Ti-6Al-4V structures,” Journal of Biomedical Materials Research. Part A, vol. 92, no. 1, pp. 56–62, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. D. L. Cochran, P. V. Nummikoski, F. L. Higginbottom, J. S. Hermann, S. R. Makins, and D. Buser, “Evaluation of an endosseous titanium implant with a sandblasted and acid-etched surface in the canine mandible: radiographic results,” Clinical Oral Implants Research, vol. 7, no. 3, pp. 240–252, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Buser, N. Broggini, M. Wieland et al., “Enhanced bone apposition to a chemically modified SLA titanium surface,” Journal of Dental Research, vol. 83, no. 7, pp. 529–533, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Buser, R. K. Schenk, S. Steinemann, J. P. Fiorellini, C. H. Fox, and H. Stich, “Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs,” Journal of Biomedical Materials Research, vol. 25, no. 7, pp. 889–902, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. Y.-T. Sul, C. B. Johansson, S. Petronis et al., “Characteristics of the surface oxides on turned and electrochemically oxidized pure titanium implants up to dielectric breakdown: the oxide thickness, micropore configurations, surface roughness, crystal structure and chemical composition,” Biomaterials, vol. 23, no. 2, pp. 491–501, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Junker, A. Dimakis, M. Thoneick, and J. A. Jansen, “Effects of implant surface coatings and composition on bone integration: a systematic review,” Clinical Oral Implants Research, vol. 20, no. 4, pp. 185–206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. J.-B. Huh, J.-Y. Lee, Y.-C. Jeon, S.-W. Shin, J.-S. Ahn, and J.-J. Ryu, “Physical stability of arginine-glycine-aspartic acid peptide coated on anodized implants after installation,” Journal of Advanced Prosthodontics, vol. 5, no. 2, pp. 84–91, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Rammelt, C. Heck, R. Bernhardt et al., “In vivo effects of coating loaded and unloaded Ti implants with collagen, chondroitin sulfate, and hydroxyapatite in the sheep tibia,” Journal of Orthopaedic Research, vol. 25, no. 8, pp. 1052–1061, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Hall, R. G. Soransen, J. M. Wozney, and U. M. E. Wikesjö, “Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model,” Journal of Clinical Periodontology, vol. 34, no. 5, pp. 444–451, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. P. C. Bessa, M. Casal, and R. L. Reis, “Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic. Part I (basic concepts),” Journal of Tissue Engineering and Regenerative Medicine, vol. 2, no. 1, pp. 1–13, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. C. Bessa, M. Casal, and R. L. Reis, “Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery),” Journal of Tissue Engineering and Regenerative Medicine, vol. 2, no. 2-3, pp. 81–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Mehta, K. Schmidt-Bleek, G. N. Duda, and D. J. Mooney, “Biomaterial delivery of morphogens to mimic the natural healing cascade in bone,” Advanced Drug Delivery Reviews, vol. 64, no. 12, pp. 1257–1276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. P. J. Boyne, R. E. Marx, M. Nevins et al., “A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation,” International Journal of Periodontics & Restorative Dentistry, vol. 17, no. 1, pp. 11–25, 1997. View at Google Scholar · View at Scopus
  19. O. Hanisch, D. N.tatakis, M. M. Boskovic, M. D. Rohrer, and U. M. E. Wikesjö, “Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2,” The International Journal of Oral & Maxillofacial Implants, vol. 12, no. 5, pp. 604–610, 1997. View at Google Scholar · View at Scopus
  20. T. H. Howell, J. Fiorellini, A. Jones et al., “A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation,” International Journal of Periodontics & Restorative Dentistry, vol. 17, no. 2, pp. 124–139, 1997. View at Google Scholar · View at Scopus
  21. T. J. Sigurdsson, L. Nygaard, D. N. Tatakis et al., “Periodontal repair in dogs: evaluation of rhBMP-2 carriers,” International Journal of Periodontics & Restorative Dentistry, vol. 16, no. 6, pp. 525–537, 1996. View at Google Scholar · View at Scopus
  22. B. J. Cole, M. P. G. Bostrom, T. L. Pritchard et al., “Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat,” Clinical Orthopaedics and Related Research, no. 345, pp. 219–228, 1997. View at Google Scholar · View at Scopus
  23. G. Herr, C.-H. Hartwig, C. Boll, and W. Küsswetter, “Ectopic bone formation by composites of BMP and metal implants in rats,” Acta Orthopaedica Scandinavica, vol. 67, no. 6, pp. 606–610, 1996. View at Publisher · View at Google Scholar · View at Scopus
  24. J.-E. Kim, S.-S. Kang, K.-H. Choi et al., “The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 115, no. 6, pp. e24–e31, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. J.-B. Huh, S.-E. Kim, H.-E. Kim et al., “Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs,” International Journal of Oral & Maxillofacial Surgery, vol. 41, no. 12, pp. 1577–1584, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. V. F. Stenport, C. Johansson, S. J. Heo, P. Aspenberg, and T. Albrektsson, “Titanium implants and BMP-7 in bone: an experimental model in the rabbit,” Journal of Materials Science: Materials in Medicine, vol. 14, no. 3, pp. 247–254, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Schliephake, A. Aref, D. Scharnweber, S. Bierbaum, S. Roessler, and A. Sewing, “Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation,” Clinical Oral Implants Research, vol. 16, no. 5, pp. 563–569, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Stadlinger, E. Pilling, M. Huhle et al., “Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study,” International Journal of Oral & Maxillofacial Surgery, vol. 37, no. 1, pp. 54–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. K. N. Leknes, J. Yang, M. Qahash, G. Polimeni, C. Susin, and U. M. E. Wikesjö, “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: radiographic observations,” Clinical Oral Implants Research, vol. 19, no. 10, pp. 1027–1033, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. U. M. E. Wikesjö, M. Qahash, G. Polimeni et al., “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: histologic observations,” Journal of Clinical Periodontology, vol. 35, no. 11, pp. 1001–1010, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Buser, S. F. M. Janner, J.-G. Wittneben, U. Brägger, C. A. Ramseier, and G. E. Salvi, “10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients,” Clinical Implant Dentistry and Related Research, vol. 14, no. 6, pp. 839–851, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. J.-K. Lee, L.-R. Cho, H.-S. Um, B.-S. Chang, and K.-S. Cho, “Bone formation and remodeling of three different dental implant surfaces with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in a rabbit model,” The International Journal of Oral & Maxillofacial Implants, vol. 28, no. 2, pp. 424–430, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. J.-B. Huh, C.-K. Park, S.-E. Kim et al., “Alveolar ridge augmentation using anodized implants coated with Escherichia coli—derived recombinant human bone morphogenetic protein 2,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 112, no. 1, pp. 42–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. D. N. Tatakis, A. Koh, L. Jin, J. M. Wozney, M. D. Rohrer, and U. M. E. Wikesjö, “Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model: a dose-response study,” Journal of Periodontal Research, vol. 37, no. 2, pp. 93–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. Y.-J. Lee, Y. Kim, J.-Y. Kim, J.-B. Huh, M.-R. Kim, and S.-J. Kim, “Effect of different concentrations of Escherichia Coli-derived rhBMP-2 coating on osseointegration of implants in dogs,” Tissue Engineering and Regenerative Medicine, vol. 9, no. 4, pp. 209–215, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. D. Botticelli, T. Berglundh, and J. Lindhe, “Resolution of bone defects of varying dimension and configuration in the marginal portion of the peri-implant bone. An experimental study in the dog,” Journal of Clinical Periodontology, vol. 31, no. 4, pp. 309–317, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. S. F. Schwarz, M. Herten, M. Sager, M. Wieland, M. Dard, and J. Becker, “Bone regeneration in dehiscence-type defects at chemically modified (SLActive) and conventional SLA titanium implants: a pilot study in dogs,” Journal of Clinical Periodontology, vol. 34, no. 1, pp. 78–86, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. F. Schwarz, M. Sager, D. Ferrari, M. Herten, M. Wieland, and J. Becker, “Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive) and conventional SLA titanium implants: an immunohistochemical study in dogs,” Journal of Clinical Periodontology, vol. 35, no. 1, pp. 64–75, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Becker, A. Kirsch, F. Schwarz et al., “Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs,” Clinical Oral Investigations, vol. 10, no. 3, pp. 217–224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. U. M. E. Wikesjö, M. Qahash, R. C. Thomson et al., “Space-providing expanded polytetrafluoroethylene devices define alveolar augmentation at dental implants induced by recombinant human bone morphogenetic protein 2 in an absorbable collagen sponge carrier,” Clinical Implant Dentistry and Related Research, vol. 5, no. 2, pp. 112–123, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Kim, Y. Park, G. Tae et al., “Characterization of low-molecular-weight hyaluronic acid-based hydrogel and differential stem cell responses in the hydrogel microenvironments,” Journal of Biomedical Materials Research Part A, vol. 88, no. 4, pp. 967–975, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. T.-C. Lee, J.-T. Ho, K.-S. Hung, W.-F. Chen, Y.-H. Chung, and Y.-L. Yang, “Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment,” Neurosurgery, vol. 58, no. 2, pp. 373–379, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. T. Takada, T. Katagiri, M. Ifuku et al., “Sulfated polysaccharides enhance the biological activities of bone morphogenetic proteins,” The Journal of Biological Chemistry, vol. 278, no. 44, pp. 43229–43235, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Zhao, T. Katagiri, H. Toyoda et al., “Heparin potentiates the in Vivo ectopic bone formation induced by bone morphogenetic protein-2,” The Journal of Biological Chemistry, vol. 281, no. 32, pp. 23246–23253, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. J.-B. Huh, S.-E. Kim, S.-K. Song et al., “The effect of immobilization of heparin and bone morphogenic protein-2 to bovine bone substitute on osteoblast-like cell's function,” Journal of Advanced Prosthodontics, vol. 3, no. 3, pp. 145–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. S. H. Lee, J. Y. Jo, M. J. Yun, Y. C. Jeon, J. B. Huh, and C. M. Jeong, “Effect of immobilization of the recombinant human bone morphogenetic protein 2 (rhBMP-2) on anodized implants coated with heparin for improving alveolar ridge augmentation in beagle dogs: radiographic observations,” The Journal of Korean Academy of Prosthodontics, vol. 51, no. 4, pp. 307–314, 2013. View at Publisher · View at Google Scholar
  47. S. E. Kim, C.-S. Kim, Y.-P. Yun et al., “Improving osteoblast functions and bone formation upon BMP-2 immobilization on titanium modified with heparin,” Carbohydrate Polymers, vol. 114, pp. 123–132, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. V. Rosen, “BMP and BMP inhibitors in bone,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 19–25, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. H. Kaneko, T. Arakawa, H. Mano et al., “Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts,” Bone, vol. 27, no. 4, pp. 479–486, 2000. View at Publisher · View at Google Scholar · View at Scopus