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BioMed Research International
Volume 2015, Article ID 473159, 10 pages
http://dx.doi.org/10.1155/2015/473159
Research Article

Full GMP-Compliant Validation of Bone Marrow-Derived Human CD133+ Cells as Advanced Therapy Medicinal Product for Refractory Ischemic Cardiomyopathy

1Laboratory of Cell Therapy “Stefano Verri”, Azienda Ospedaliera San Gerardo, Via Pergolesi 33, 20900 Monza, Italy
2Department of Health Science, Università degli Studi di Milano-Bicocca, piazza dell’Ateneo Nuovo 1, 20126 Milan, Italy
3Tettamanti Research Center, Azienda Ospedaliera San Gerardo, Via Pergolesi 33, 20900 Monza, Italy
4Laboratory of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milan, Italy
5Department of Pediatrics, MBBM Foundation, Ospedale San Gerardo, Via Pergolesi 33, 20900 Monza, Italy
6Department of Ematology, Azienda Ospedaliera San Gerardo, Via Pergolesi 33, 20900 Monza, Italy
7Department of Cardiovascular Surgery, Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138 Milan, Italy
8Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy

Received 19 March 2015; Accepted 11 May 2015

Academic Editor: Sebastiano Sciarretta

Copyright © 2015 Daniela Belotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Nicolas Noiseux, Samer Mansour, Richard Weisel, Louis-Mathieu Stevens, Shant Der Sarkissian, Katherine Tsang, Andrew M. Crean, Eric Larose, Shu-Hong Li, Bernd Wintersperger, Minh Quan Vu, Ignacio Prieto, Ren-Ke Li, Denis Claude Roy, and Terrence M. Yau, “The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy,” The Journal of Thoracic and Cardiovascular Surgery, 2016. View at Publisher · View at Google Scholar
  • Gabriella Spaltro, Daniele Avitabile, Elena De Falco, and Elisa Gambini, “Physiological conditions influencing regenerative potential of stem cells,” Frontiers In Bioscience-Landmark, vol. 21, pp. 1126–1150, 2016. View at Publisher · View at Google Scholar
  • David A. Grainger, Amit N. Patel, Hallie Thorp, Donald L. Atkinson, Francisco J. Silva, Edward W. Hsu, Amalia A. Winters, Sophia Bou-Ghannam, Jose A. Hawayek, Courtney E. Bartlett, and Alonso P. Moreno, “Evaluation of multiple biological therapies for ischemic cardiac disease,” Cell Transplantation, vol. 25, no. 9, pp. 1591–1607, 2016. View at Publisher · View at Google Scholar
  • Patrizia Nigro, Beatrice Bassetti, Laura Cavallotti, Valentina Catto, Corrado Carbucicchio, and Giulio Pompilio, “Cell therapy for heart disease after 15 years: Unmet expectations,” Pharmacological Research, 2017. View at Publisher · View at Google Scholar
  • Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A. Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki, Ulrike Ruch, Gudrun Tiedemann, Robert David, and Gustav Steinhoff, “GMP-conformant on-site manufacturing of a CD133+ stem cell product for cardiovascular regeneration,” Stem Cell Research & Therapy, vol. 8, no. 1, 2017. View at Publisher · View at Google Scholar
  • Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, Alberto Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella, Felice Achilli, and Giulio Pompilio, “Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133+ cells in ischemic refractory cardiomyopathy trial (RECARDIO),” Stem Cell Research & Therapy, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar