Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 485732, 5 pages
http://dx.doi.org/10.1155/2015/485732
Research Article

Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation

1Radiation Therapy Oncology Unit, Second Department of Radiology, University Hospital of Athens “ATTIKON”, Rimini 1, Haidari, 124 64 Athens, Greece
2Oncology Clinic, 401 General Military Hospital, Mesogeion 138 & Katehaki, 115 25 Athens, Greece
3Department of Radiotherapy, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110 Larissa, Greece
4Pammakaristos General Hospital, Iakovaton 43, 11144 Athens, Greece
5Radiation Therapy Oncology Department, First Department of Radiology, Aretaieion Hospital, University of Athens Medical School, Vassilissis Sofias 76, 115 28 Athens, Greece
6Biochemistry Department, 401 General Military Hospital, Mesogeion 138 & Katehaki, 115 25 Athens, Greece
7Oncology Clinic, University Hospital of Athens “ATTIKON”, Rimini 1, Haidari, 124 64 Athens, Greece
8Radiation Oncology Clinic, University Hospital of Thessaloniki AHEPA, 1 Street Kyriakidi, 54636 Thessaloniki, Greece

Received 9 September 2014; Revised 9 March 2015; Accepted 12 March 2015

Academic Editor: Olive Joy Wolfe

Copyright © 2015 Maria Tolia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To identify whether the serum’s baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC). Methods. In total, 100 consecutive patients (mean age = 68.38 ± 10.85 years) that underwent chemoradiotherapy were studied. Measurements of CRP and Alb were performed before any treatment. Results. Serum CRP levels were significantly associated with histological grade , TNM stage , PS , and Alb . Additionally CRP and Alb levels were found significantly associated with overall survival in univariate analysis (log-rank test, and , resp.) and CRP remained significant after controlling for age, alcohol, performance status, and TNM stage, whereas albumin showed a borderline effect on the hazard rate . Conclusions. CRP and Alb are both promising biomarkers in identification of NSCLC patients with poor prognosis and form a possible target for intensifying their therapies.