An Integrated Modeling and Experimental Approach to Study the Influence of Environmental Nutrients on Biofilm Formation of Pseudomonas aeruginosa

Figure 8

Schematic representation of the flux balance analysis approach on studying the microorganism metabolism. (a) A small fraction of the metabolic reactions taken from the metabolic model, (b) the mathematical representation of the metabolic reaction networks where S is the stoichiometric matrix, is the biomass growth rate, v is the flux vector, and and are the lower and upper bounds of flux , and (c) the optimal growth rate and metabolite production rates , = 1, 2, and 3, determined from the solution space via the flux balance analysis. Three fluxes are used here for the purpose of illustration.

(a)

(b)

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