Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

<div>Time line of  RA rat model. 1st (■) and 2nd (■) immunization, DTH (♦), i.a. injection <svg height="12.0395pt" id="M7" style="vertical-align:-2.3616pt" version="1.1" viewbox="-0.0498162 -9.6779 15.5345 12.0395" width="15.5345pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g><g transform="matrix(.0136,0,0,-0.0136,4.688,0)"><path d="M394 692H49V0H394V692Z"></path><glyph.data ascent="900" descent="-389" horiz-adv-x="443" vert-adv-y="443"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,10.69,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z" id="g113-42"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="346" vert-adv-y="346"></glyph.data></g></svg>, boost i.a. injections (▲), PET and/or, ex vivo tissue distribution, and (immuno-) histopathology of groups A (6 d), B (28 d), C (19 d), D (28 d), E (saline, 6 d), and F (saline, 28 d) (▼).</div>

BioMed Research International

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Figure 1

Figure 1: Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation 

Figure 1 | Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation 