Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

Figure 2

(a) Measurement of anti-mBSA in serum in rats before immunization (left) and after immunization (right) (). (b) Caliper measurement of right ear swelling of (■) A (6 d); (♦) B (28 d); (●) C (19 d); (▲) D (28 d), compared to the control ear of (□) A (6 d); (◊) B (28 d); (○) C (19 d); (∆) D (28 d), as a response to s.c. injection of antigen (). (c). Knee thickness of arthritic knee of (□) A (6 d); (◊) B (28 d); (○) C (19 d); (∆) D (28 d), compared to control Con-RA knee of (■) A (6 d); (♦) B (28 d); (●) C (19 d); (▲) D (28 d). All results depicted represent mean ± SD.

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