Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

Figure 3

Immunohistochemistry. Images (200x) of ED1 (upper panel) and ED2 (lower panel) staining in knees of healthy rats (left panel; limited amounts of macrophages); knees from rats in the no boost groups (A (6 d) and B (28 d)); showing clear influx of positively stained ED1 and ED2 macrophages in the inflamed synovium; knees from rats in the boost groups C (19 d) and D (28 d); showing strong influx of positively stained ED1 and ED2 macrophages in the multilayered synovial linings.