Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation

Figure 4

Macrophage counting in histological knee sections. (A) Total number (±SD) of ED1 positive macrophages in the lining and sublining of the knee synovial tissue from the no boost rats (A (6 d) and B (28 d)); RA knee, light grey bars, Con-RA knee, black bars. (B) Total number (±SD) of ED1 positive macrophages in the lining and sublining of the knee synovial tissue from the groups B (28 d), C (19 d), and D (28 d) are added next to saline control rats group F (28 d). (C (19 d)) Total number (±SD) of ED2 positive macrophages in the lining and sublining of the knee synovial tissue from the groups B (28 d), C (19 d), and D (28 d) are added next to saline control rats group F (28 d).

(a)

(b)

(c)