N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms

Figure 1

Effects of SA on body weight changes in HFD-fed rats over 12 weeks. (a) Total body weight changes. (b) Percentage of body weight changes. Groups are the same as Table 1. No significant differences were observed between the groups’ actual weights, but total weight gain was the highest in the HFD and normal groups (50% and 47%, resp.), while the HFD + simvastatin group had the lowest (40% increase), followed by the HFD + SAH and HFD + SAL groups (42% and 46%, resp.).

(a)

(b)