MicroRNA and mRNA Features of Malignant Pleural Mesothelioma and Benign Asbestos-Related Pleural Effusion

Table 5

Overexpressed genes that are also targeted by downregulated microRNAs in pathways from Table 4.

	miRNA data				mRNA data
	miR-19a	miR-29c	miR-449a	miR-511	Probeset	P-MPM > BAPE	Fold change
MET			X		203510_at	0.0067	15.56
WNT3	X				229103_at	0	8.75
HDAC4	X	X			204225_at	0.0071	4.92
CDK6		X	X		224848_at	0.0069	4.26
RXRA	X				202449_s_at	0.0015	3.51
TBL1XR1			X		222634_s_at	0.0076	2.87
EIF2C2				X	213310_at		2.83
MTMR4		X			212277_at	0.0089	2.81
CCNE2			X		205034_at	0.0036	2.48
COL12A1			X		231879_at	0.0093	2.45
SMARCA2	X				212257_s_at	0.0099	2.36
EIF2C1	X	X		X	228120_at	0.002	1.93
SEMA4F			X		228660_x_at		1.82
RAF1	X				1557675_at	0.0077	1.77
TFDP2			X		244043_at	0.0093	1.47

values in microRNAs columns are for MPM < BAPE.
MPM: malignant pleural mesothelioma; BAPE: benign asbestos-related pleural effusion.