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BioMed Research International
Volume 2015, Article ID 673018, 7 pages
http://dx.doi.org/10.1155/2015/673018
Research Article

Is Lipoprotein-Associated Phospholipase A2 a Link between Inflammation and Subclinical Atherosclerosis in Rheumatoid Arthritis?

1Department of Public Health and Clinical Medicine/Rheumatology, University of Umeå, 901 87 Umeå, Sweden
2Department of Surgical and Perioperative Sciences, University of Umeå, 901 87 Umeå, Sweden
3Department of Rheumatology, Östersund Hospital, 831 27 Östersund, Sweden
4Department of Rheumatology, Sunderby Hospital, 971 89 Luleå, Sweden

Received 7 March 2015; Accepted 23 April 2015

Academic Editor: Giuseppe Biondi-Zoccai

Copyright © 2015 Anna Södergren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods. Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients ≤60 years () were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age- and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. Results. There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (). In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score (). Conclusion. In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity.