PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis

Figure 4

Role of PLK-1 in DNA damage based induction of tumorigenesis. In DNA damage response, overexpression of PLK1 degrades and/or inactivates the p53 in TOPORS and GTSE1 dependent manner (Figure 3). Consequently, cell enters in mitotic phase with high load of genomic defects. G2/M transition, PLK-1 dephosphorylates CDK-1 by activated CDC25C and also inhibits the CDK-1 activator WEE1/MYT1 to onset the mitotic entry with genomic defects and cause the tumorigenesis.