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BioMed Research International
Volume 2015, Article ID 708158, 9 pages
http://dx.doi.org/10.1155/2015/708158
Research Article

Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage

1The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
2Cancer Biology Research Center, Sanford Research/University of South Dakota, Sioux Falls, SD 57104, USA
3The Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA

Received 29 November 2014; Revised 8 March 2015; Accepted 9 March 2015

Academic Editor: Peter Jordan

Copyright © 2015 Marie-Jo Halaby et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Description of Results: We observed that overexpression of RHA leads to enhanced p53 IRES activity under normal growth conditions (Figure S1A). However, in contrast to overexpression of TCP80 (Fig. 1B), overexpression of RHA cannot lead to a further increase in p53 IRES activity following DNA damage (Figure S1B).

  1. Supplementary Material