BioMed Research International

Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology


Status
Published

Lead Editor

1Institute of Molecular Genetics, National Research Council (IGM-CNR), Pavia, Italy

2Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Middlesex County, NJ, USA

3Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal

4Department of Movement, Human, and Health Sciences, Foro Italico University of Rome, Laboratory of Cellular and Molecular Neurobiology, (CERC) Fondazione Santa Lucia, Rome, Italy


Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology

Description

In order to support tumor growth, invasion, and metastasis, cancer cells rapidly and efficiently affect the expression and the functions of their proteome through a variety of mechanism, including the regulation of posttranscriptional events, such as pre-mRNA splicing, modifications of mRNA stability and/or translational efficiency, RNA editing, and noncoding RNAs.

RNA binding proteins (RBPs) play a pivotal role in these processes and they are aberrantly expressed in several tumor types. Moreover, each RBP regulates hundreds of targets at the same time, thus leading to important consequences for cancer cell biology. A thorough understanding of the role of posttranscriptional regulation and RBPs in tumorigenesis will lead to a better comprehension of the molecular events that trigger malignant transformation and will contribute to the development of more selective and effective anticancer therapies.

We invite authors to contribute original research articles as well as review articles that will illustrate and stimulate the continuing effort to understand the implication of posttranscriptional regulation of gene expression in cancer and to exploit manipulation of the function of selected RBPs or noncoding RNAs as diagnostic/predictive biomarkers or potential targets for the development of innovative therapeutic strategies.

Potential topics include, but are not limited to:

  • Recent discoveries of the roles of posttranscriptional regulation in cancer
  • Functional characterization of RBPs and noncoding RNAs aberrantly expressed in tumor tissues
  • Identification and functional description of new RNA targets (and regulatory elements) of RBPs involved in tumor initiation, maintenance, or the development of resistance to treatments
  • Posttranscriptional regulation events and RBPs as targets in anticancer therapies
  • Bioinformatics approaches to characterize the regulatory networks formed by RNA binding proteins and their target RNAs in aspects of cancer cell biology

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 146250
  • - Research Article

An Association Rule Mining Approach to Discover lncRNAs Expression Patterns in Cancer Datasets

Paolo Cremaschi | Roberta Carriero | ... | Silvia Bione
  • Special Issue
  • - Volume 2015
  • - Article ID 897821
  • - Editorial

Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology

Claudia Ghigna | Luca Cartegni | ... | Maria Paola Paronetto
  • Special Issue
  • - Volume 2015
  • - Article ID 543067
  • - Review Article

Splicing Regulation: A Molecular Device to Enhance Cancer Cell Adaptation

Vittoria Pagliarini | Chiara Naro | Claudio Sette
  • Special Issue
  • - Volume 2015
  • - Article ID 708158
  • - Research Article

Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage

Marie-Jo Halaby | Yan Li | ... | Da-Qing Yang
  • Special Issue
  • - Volume 2015
  • - Article ID 672759
  • - Review Article

Emerging Roles of MicroRNAs in EGFR-Targeted Therapies for Lung Cancer

Fei Han | Jinxi He | ... | Xiaoming Liu
  • Special Issue
  • - Volume 2015
  • - Article ID 528954
  • - Review Article

SAM68: Signal Transduction and RNA Metabolism in Human Cancer

Paola Frisone | Davide Pradella | ... | Maria Paola Paronetto
  • Special Issue
  • - Volume 2015
  • - Article ID 395816
  • - Research Article

Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells

Elaine Hong | Andrew Best | ... | Alison J. Tyson-Capper
  • Special Issue
  • - Volume 2015
  • - Article ID 287048
  • - Review Article

Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

Vânia Gonçalves | Peter Jordan
  • Special Issue
  • - Volume 2015
  • - Article ID 150514
  • - Review Article

Splicing Regulators and Their Roles in Cancer Biology and Therapy

Maria Roméria da Silva | Gabriela Alves Moreira | ... | Gustavo Costa Bressan
BioMed Research International
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Acceptance rate31%
Submission to final decision67 days
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