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BioMed Research International
Volume 2015 (2015), Article ID 735615, 18 pages
Review Article

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

1Department of Internal Medicine and Biomedicine, University of Palermo, 90100 Palermo, Italy
2Department of Human Pathology, University of Messina, 98125 Messina, Italy
3IFC CNR, Messina Unit, 98100 Messina, Italy
4Infectious Diseases Unit, Papardo-Piemonte Hospital, 98125 Messina, Italy
5AILMI-ONLUS Italian Association for the Control of Infectious Diseases, University of Messina, 98125 Messina, Italy

Received 19 November 2014; Revised 18 February 2015; Accepted 2 March 2015

Academic Editor: Daniel Teta

Copyright © 2015 Pasquale Mansueto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.