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BioMed Research International
Volume 2015 (2015), Article ID 825397, 6 pages
http://dx.doi.org/10.1155/2015/825397
Research Article

Presence of Periodontopathic Bacteria DNA in Atheromatous Plaques from Coronary and Carotid Arteries

1Department of Periodontology, Wroctaw Medical University, Ulica Krakowska 26, 50-425 Wroctaw, Poland
2Department of Cardiac Surgery, Wroctaw Medical University, Ulica Borowska 213, 50-556 Wrocław, Poland
3Department of Vascular, General and Transplantation Surgery, Wroctaw Medical University, Ulica Borowska 213, 50-556 Wrocław, Poland
4Department of Forensic Medicine, Molecular Techniques Unit, Wroctaw Medical University, Ulica M. Curie-Skłodowskiej 52, 50-369 Wrocław, Poland
5Division of Oral Pathology, Department of Periodontology, Wroctaw Medical University, Ulica Krakowska 26, 50-425 Wroctaw, Poland

Received 26 February 2015; Revised 16 May 2015; Accepted 18 May 2015

Academic Editor: Giuseppe Biondi-Zoccai

Copyright © 2015 Malgorzata Szulc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. Interest in periodontitis as a potential risk factor for atherosclerosis and its complications resulted from the fact that the global prevalence of periodontal diseases is significant and periodontitis may induce a chronic inflammatory response. Many studies have analyzed the potential impact of the Porphyromonas gingivalis, major pathogen of periodontitis, on general health. The purpose of this study was to find the presence of the Porphyromonas gingivalis DNA in the atherosclerotic plaques of coronary and carotid arteries and in the periodontal pockets in patients with chronic periodontitis, who underwent surgery because of vascular diseases. Methods and Results. The study population consisted of 91 patients with coronary artery disease or scheduled for carotid endarterectomy. The presence of Porphyromonas gingivalis DNA in atheromatous plaques and in subgingival samples was determined by PCR. Bacterial DNA was found in 21 of 91 (23%) samples taken from vessels and in 47 of 63 (74.6%) samples from periodontal pockets. Conclusions. Porphyromonas gingivalis DNA is frequently found in atheromatous plaques of patients with periodontitis. That is why more research should be conducted to prove if this periopathogen may have an impact on endothelium of patients at risk of atherosclerosis.