BioMed Research International / 2015 / Article / Tab 2

Research Article

Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility

Table 2

Spearman’s rank correlation between the genotype of rs2872507 (number of susceptibility alleles) and gene expression (dCt-values) in intestinal biopsy samples from different study groups.

GenesNI_N_ilNI_N_coIBD_N_ilIBD_N_coIBD_I_coCD_N_ilCD_N_coUC_N_ilUC_N_coUC_I_co
= 24 = 33 = 24 = 29 = 28 = 11 = 12 = 12 = 16 = 19
P valueP valueP valueP valueP valueP valueP valueP valueP valueP value

PGAP30.376.8 × 10−032.0 × 10−030.0190.0170.0300.430.290.0600.59
ERBB20.640.570.690.270.230.910.310.500.680.89
MIEN10.660.890.0340.150.500.790.350.0850.0230.27
GRB70.930.710.210.610.990.510.930.310.930.50
IKZF30.880.850.690.430.470.420.390.800.920.27
ZPBP20.240.590.840.330.177.7 × 10−040.950.760.0780.064
GSDMB2.4 × 10−033.7 × 10−041.5 × 10−037.2 × 10−104.1 × 10−033.8 × 10−036.2 × 10−060.0351.9 × 10−040.045
ORMDL30.920.770.0370.350.470.0160.630.240.0450.22
LRRC3C0.837.8 × 10−060.920.0580.420.790.580.210.240.27
GSDMA0.0161.6 × 10−040.920.280.150.280.500.740.500.86
PSMD30.870.380.510.0140.430.450.0570.660.140.32
CSF30.420.450.610.660.810.770.310.250.170.10
MED240.390.430.166.9 × 10−030.610.500.0850.760.0930.21

Disease status_Inflammatory status_sampling location; the disease statuses are Crohn’s disease (CD), inflammatory bowel disease (IBD), non-IBD (NI), and ulcerative colitis (UC); the inflammatory statuses are inflamed (I) and noninflamed (N); the sampling locations are colon (co) and ileum (il).
Genes have been arranged (top to bottom) in the order in which they are positioned along the chromosome, and the risk locus (rs2872507) is located between ZPBP2 and GSDMB (closer to ZPBP2).