BioMed Research International / 2015 / Article / Tab 3

Research Article

Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility

Table 3

Inflammatory effects on the colonic mucosal expression of genes in the IBD risk locus (rs2872507).

Genes IBD_N_co ( = 29) versus IBD_I_co ( = 28) UC_N_co ( = 16) versus UC_I_co ( = 19) CD_N_co ( = 12) versus CD_I_co ( = 7)
P valueFold changeP valueFold changeP valueFold change

PGAP33.7 × 10−099.8 × 10−064.5 × 10−04
ERBB21.0 × 10−093.9 × 10−066.2 × 10−04
MIEN11.0 × 10−040.0140.010
GRB71.7 × 10−072.9 × 10−048.4 × 10−04
IKZF32.4 × 10−076.6 × 10−056.0 × 10−03
ZPBP20.210.270.58
GSDMB0.310.330.97
ORMDL30.650.560.64
LRRC3C0.0160.180.083
GSDMA0.480.960.29
PSMD30.0240.0300.33
CSF33.5 × 10−084.3 × 10−052.7 × 10−03
MED246.5 × 10−039.3 × 10−030.42

Disease status_Inflammatory status_sampling location; the disease statuses are Crohn’s disease (CD), inflammatory bowel disease (IBD), and ulcerative colitis (UC); the inflammatory statuses are inflamed (I) and noninflamed (N); the sampling locations are colon (co) and ileum (il).
Genes have been arranged (top to bottom) in the order in which they are positioned along the chromosome.
A negative fold change indicates reduced expression in the inflamed tissue compared with that in the noninflamed tissue.