POD-1/TCF21 Reduces SHP Expression, Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma Tumor Cells

Table 1

Nucleotide sequence and E-box elements identified in  silico using MatInspector.

Identified E-box	Species	Sequence
AR E-box -1135	Human	5′-atgccaCGAGgcc-3′
	Mouse	5′-gtgtcaggaattc-3′
LRH-1 E-box -53	Human	3′-tcatcaCATGact-5′
	Mouse	3′-tggtcacatgacc-5′
LRH-1 E-box -1300	Human	5′-tggccaGGTGcgg-3′
	Mouse	5′-ttgccttcagtgc-3′
SHP E-box -177	Human	5′-gtgccaCGTGggg-3′
	Mouse	5′-aggccacgtggagc-3′
SHP E-box -3702	Human	3′-ggaTCACttgagg-5′
	Mouse	3′-agatctctcagct-3′

E-box elements were named based on distance to transcriptional start, as shown in Figure 3. Core human sequence elements, as identified by MatInspector (see Section 2), are shown in capitals.
Nucleotides conserved, in human and mouse, are shown underlined in the mouse sequence; sequence alignment was done using Clustalw2 (http://www.ebi.ac.uk/Tools/msa/clustalw2/), under default settings.