PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury

Figure 2

Effect of WY-14643 administration in NAMPT protein expression and NAD⁺/NADH levels. (a) Western blot and densitometric analysis of NAMPT. (b) Photometric analysis of NAD⁺/NADH levels in steatotic livers after 24 hours of reperfusion. Sham: anesthesia and laparotomy, IR: 60 min partial ischemia and 24 h of reperfusion, and WY-14643 + IR: iv administration of WY-14643 (10 mg/kg) 1 hour before IR. versus Sham; versus IR.

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