Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 929806, 9 pages
http://dx.doi.org/10.1155/2015/929806
Review Article

microRNA Regulation of Peritoneal Cavity Homeostasis in Peritoneal Dialysis

Department of Nephrology, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Heath Park Campus, Cardiff CF14 4XN, UK

Received 22 June 2015; Accepted 9 August 2015

Academic Editor: Janusz Witowski

Copyright © 2015 Melisa Lopez-Anton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. S. Aroeira, A. Aguilera, J. A. Sánchez-Tomero et al., “Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: Pathologic significance and potential therapeutic interventions,” Journal of the American Society of Nephrology, vol. 18, no. 7, pp. 2004–2013, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Selgas, A. Bajo, J. A. Jiménez-Heffernan et al., “Epithelial-to-mesenchymal transition of the mesothelial cell—its role in the response of the peritoneum to dialysis,” Nephrology Dialysis Transplantation, vol. 21, no. 2, pp. ii2–ii7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Loureiro, A. Aguilera, R. Selgas et al., “Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage,” Journal of the American Society of Nephrology, vol. 22, no. 9, pp. 1682–1695, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Wightman, I. Ha, and G. Ruvkun, “Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans,” Cell, vol. 75, no. 5, pp. 855–862, 1993. View at Publisher · View at Google Scholar · View at Scopus
  5. R. C. Lee, R. L. Feinbaum, and V. Ambros, “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14,” Cell, vol. 75, no. 5, pp. 843–854, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Landgraf, M. Rusu, R. Sheridan et al., “A mammalian microRNA expression atlas based on small RNA library sequencing,” Cell, vol. 129, no. 7, pp. 1401–1414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. G. M. Borchert, W. Lanier, and B. L. Davidson, “RNA polymerase III transcribes human microRNAs,” Nature Structural and Molecular Biology, vol. 13, no. 12, pp. 1097–1101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Lee, M. Kim, J. Han et al., “MicroRNA genes are transcribed by RNA polymerase II,” The EMBO Journal, vol. 23, no. 20, pp. 4051–4060, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Lee, K. Jeon, J.-T. Lee, S. Kim, and V. N. Kim, “MicroRNA maturation: stepwise processing and subcellular localization,” The EMBO Journal, vol. 21, no. 17, pp. 4663–4670, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Lee, C. Ahn, J. Han et al., “The nuclear RNase III Drosha initiates microRNA processing,” Nature, vol. 425, no. 6956, pp. 415–419, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Yi, Y. Qin, I. G. Macara, and B. R. Cullen, “Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs,” Genes and Development, vol. 17, no. 24, pp. 3011–3016, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Grishok, A. E. Pasquinelli, D. Conte et al., “Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing,” Cell, vol. 106, no. 1, pp. 23–34, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Bernstein, A. A. Caudy, S. M. Hammond, and G. J. Hannon, “Role for a bidentate ribonuclease in the initiation step of RNA interference,” Nature, vol. 409, no. 6818, pp. 363–366, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. A. E. Pasquinelli, “MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship,” Nature Reviews Genetics, vol. 13, no. 4, pp. 271–282, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. B. D. Brown and L. Naldini, “Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications,” Nature Reviews Genetics, vol. 10, no. 8, pp. 578–585, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. A. Cortez, C. Bueso-Ramos, J. Ferdin, G. Lopez-Berestein, A. K. Sood, and G. A. Calin, “MicroRNAs in body fluids-the mix of hormones and biomarkers,” Nature Reviews Clinical Oncology, vol. 8, no. 8, pp. 467–477, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Kota, R. R. Chivukula, K. A. O'Donnell et al., “Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model,” Cell, vol. 137, no. 6, pp. 1005–1017, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Turchinovich, L. Weiz, A. Langheinz, and B. Burwinkel, “Characterization of extracellular circulating microRNA,” Nucleic Acids Research, vol. 39, no. 16, pp. 7223–7233, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Zhou, M. Yang, H. Lan, and X. Yu, “MiR-30a negatively regulates TGF-β1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting snai1,” American Journal of Pathology, vol. 183, no. 3, pp. 808–819, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. J.-W. Yu, W.-J. Duan, X.-R. Huang, X.-M. Meng, X.-Q. Yu, and H.-Y. Lan, “MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis,” Laboratory Investigation, vol. 94, no. 9, pp. 978–990, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. H. J. Bos, D. G. Struijk, C. W. Tuk et al., “Peritoneal dialysis induces a local sterile inflammatory state and the mesothelial cells in the effluent are related to the bacterial peritonitis incidence,” Nephron, vol. 59, no. 3, pp. 508–509, 1991. View at Publisher · View at Google Scholar · View at Scopus
  22. M. F. de Castro, R. Selgas, C. Jimenez et al., “Cell populations present in the nocturnal peritoneal effluent of patients on continuous ambulatory peritoneal dialysis and their relationship with peritoneal function and incidence of peritonitis,” Peritoneal Dialysis International, vol. 14, no. 3, pp. 265–270, 1994. View at Google Scholar · View at Scopus
  23. M. Yáñez-Mó, E. Lara-Pezzi, R. Selgas et al., “Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells,” The New England Journal of Medicine, vol. 348, no. 5, pp. 403–413, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Lameire, W. Van Biesen, M. Van Landschoot et al., “Experimental models in peritoneal dialysis: a European experience,” Kidney International, vol. 54, no. 6, pp. 2194–2206, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. G. T. González-Mateo, J. Loureiro, J. A. Jiménez-Hefferman et al., “Chronic exposure of mouse peritoneum to peritoneal dialysis fluid: structural and functional alterations of the peritoneal membrane,” Peritoneal Dialysis International, vol. 29, no. 2, pp. 227–230, 2009. View at Google Scholar · View at Scopus
  26. F. Lin, X. Wu, H. Zhang et al., “A microrna screen to identify regulators of peritoneal fibrosis in a rat model of peritoneal dialysis,” BMC Nephrology, vol. 16, article 48, 2015. View at Google Scholar
  27. C.-W. Cheng, H.-W. Wang, C.-W. Chang et al., “microRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer,” Breast Cancer Research and Treatment, vol. 134, no. 3, pp. 1081–1093, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Kumarswamy, G. Mudduluru, P. Ceppi et al., “MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer,” International Journal of Cancer, vol. 130, no. 9, pp. 2044–2053, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Liu, N. Zhang, and D. Tian, “MiR-30b is involved in methylglyoxal-induced epithelial-mesenchymal transition of peritoneal mesothelial cells in rats,” Cellular and Molecular Biology Letters, vol. 19, no. 2, pp. 315–329, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Wang, Q. Chen, T. C. Simon et al., “Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy,” Kidney International, vol. 63, no. 6, pp. 2037–2049, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Zeisberg, J.-I. Hanai, H. Sugimoto et al., “BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury,” Nature Medicine, vol. 9, no. 7, pp. 964–968, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Liu, R. Guo, G. Hao et al., “The expression profiling and ontology analysis of noncoding rnas in peritoneal fibrosis induced by peritoneal dialysis fluid,” Gene, vol. 564, pp. 210–219, 2015. View at Google Scholar
  33. L. Xiao, X. Zhou, F. Liu et al., “MicroRNA-129-5p modulates epithelial-to-mesenchymal transition by targeting SIP1 and SOX4 during peritoneal dialysis,” Laboratory Investigation, vol. 95, no. 7, pp. 817–832, 2015. View at Publisher · View at Google Scholar
  34. K. Zhang, H. Zhang, X. Zhou et al., “miRNA589 regulates epithelial-mesenchymal transition in human peritoneal mesothelial cells,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 673096, 6 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Zhang, F. Liu, Y. Peng, L. Sun, and G. Chen, “Changes in expression of four molecular marker proteins and one microRNA in mesothelial cells of the peritoneal dialysate effluent fluid of peritoneal dialysis patients,” Experimental and Therapeutic Medicine, vol. 6, no. 5, pp. 1189–1193, 2013. View at Google Scholar · View at Scopus
  36. J. Chen, P. Kam-Tao, B. C.-H. Kwan et al., “Relation between microRNA expression in peritoneal dialysis effluent and peritoneal transport characteristics,” Disease Markers, vol. 33, no. 1, pp. 35–42, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. J. F. Bao, J. Hao, J. Liu, W. J. Yuan, and Q. Yu, “The abnormal expression level of microrna in epithelial-mesenchymal transition of peritoneal mesothelial cells induced by high glucose,” European Review for Medical and Pharmacological Sciences, vol. 19, pp. 289–292, 2015. View at Google Scholar
  38. Y. Zhang, X.-R. Huang, L.-H. Wei, A. C. Chung, C.-M. Yu, and H.-Y. Lan, “miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling,” Molecular Therapy, vol. 22, no. 5, pp. 974–985, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Roderburg, G.-W. Urban, K. Bettermann et al., “Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis,” Hepatology, vol. 53, no. 1, pp. 209–218, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. L. Cushing, P. P. Kuang, J. Qian et al., “miR-29 is a major regulator of genes associated with pulmonary fibrosis,” American Journal of Respiratory Cell and Molecular Biology, vol. 45, no. 2, pp. 287–294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. W. Qin, A. C. K. Chung, X. R. Huang et al., “TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29,” Journal of the American Society of Nephrology, vol. 22, no. 8, pp. 1462–1474, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. A.-C. Poncelet and H. W. Schnaper, “Sp1 and smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(i) collagen expression in human glomerular mesangial cells,” The Journal of Biological Chemistry, vol. 276, no. 10, pp. 6983–6992, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Liu, L.-C. Wu, J. Pang et al., “Sp1/NFκB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia,” Cancer Cell, vol. 17, no. 4, pp. 333–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Wang, P. Koh, C. Winbanks et al., “miR-200a prevents renal fibrogenesis through repression of TGF-β2 expression,” Diabetes, vol. 60, no. 1, pp. 280–287, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Yang, S. Banerjee, A. de Freitas et al., “Participation of miR-200 in pulmonary fibrosis,” The American Journal of Pathology, vol. 180, no. 2, pp. 484–493, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Y. Z. Li, T. Y. Yong, M. Z. Michael, and J. M. Gleadle, “Review: the role of microRNAs in kidney disease,” Nephrology, vol. 15, no. 6, pp. 599–608, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Lambie, J. Chess, K. L. Donovan et al., “Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival,” Journal of the American Society of Nephrology, vol. 24, no. 12, pp. 2071–2080, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. D. W. Johnson, M. Clarke, V. Wilson, F. Woods, and F. G. Brown, “Rationale and design of the balANZ trial: a randomised controlled trial of low GDP, neutral pH versus standard peritoneal dialysis solution for the preservation of residual renal function,” BMC Nephrology, vol. 11, no. 1, article 25, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Kozomara and S. Griffiths-Jones, “miRBase: annotating high confidence microRNAs using deep sequencing data,” Nucleic Acids Research, vol. 42, no. 1, pp. D68–D73, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. J. A. Weber, D. H. Baxter, S. Zhang et al., “The microRNA spectrum in 12 body fluids,” Clinical Chemistry, vol. 56, no. 11, pp. 1733–1741, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. Biomarkers Definitions Working Group, “Biomarkers and surrogate endpoints: preferred definitions and conceptual framework,” Clinical Pharmacology and Therapeutics, vol. 69, no. 3, pp. 89–95, 2001. View at Google Scholar
  52. J. K. Aronson, “Biomarkers and surrogate endpoints,” British Journal of Clinical Pharmacology, vol. 59, no. 5, pp. 491–494, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Sturgeon, R. Hill, G. L. Hortin, and D. Thompson, “Taking a new biomarker into routine use—a perspective from the routine clinical biochemistry laboratory,” Proteomics—Clinical Applications, vol. 4, no. 12, pp. 892–903, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. J. D. Williams, K. J. Craig, N. Topley et al., “Morphologic changes in the peritoneal membrane of patients with renal disease,” Journal of the American Society of Nephrology, vol. 13, no. 2, pp. 470–479, 2002. View at Google Scholar · View at Scopus
  55. S. J. Davies, L. Phillips, A. M. Griffiths, L. H. Russell, P. F. Naish, and G. I. Russell, “What really happens to people on long-term peritoneal dialysis?” Kidney International, vol. 54, no. 6, pp. 2207–2217, 1998. View at Publisher · View at Google Scholar · View at Scopus
  56. C. E. Visser, J. J. E. Brouwer-Steenbergen, M. G. H. Betjes, G. C. M. Koomen, R. H. J. Beelen, and R. T. Krediet, “Cancer antigen 125: a bulk marker for the mesothelial mass in stable peritoneal dialysis patients,” Nephrology Dialysis Transplantation, vol. 10, no. 1, pp. 64–69, 1995. View at Google Scholar · View at Scopus
  57. M. M. Ho-Dac-Pannekeet, J. K. Hiralall, D. G. Struijk, and R. T. Krediet, “Longitudinal follow-up of CA125 in peritoneal effluent,” Kidney International, vol. 51, no. 3, pp. 888–893, 1997. View at Publisher · View at Google Scholar · View at Scopus
  58. D. Lopes Barreto and R. T. Krediet, “Current status and practical use of effluent biomarkers in peritoneal dialysis patients,” The American Journal of Kidney Diseases, vol. 62, no. 4, pp. 823–833, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. K. N. Lai, K. B. Lai, C. C. Szeto et al., “Dialysate cell population and cancer antigen 125 in stable continuous ambulatory peritoneal dialysis patients: their relationship with transport parameters,” American Journal of Kidney Diseases, vol. 29, no. 5, pp. 699–705, 1997. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Brȩborowicz, M. Brȩborowicz, M. Pyda, A. Połubinska, and D. Oreopoulos, “Limitations of CA125 as an index of peritoneal mesothelial cell mass,” Nephron. Clinical Practice, vol. 100, no. 2, pp. c46–c51, 2005. View at Publisher · View at Google Scholar · View at Scopus
  61. S. A. Jones, D. J. Fraser, C. A. Fielding, and G. W. Jones, “Interleukin-6 in renal disease and therapy,” Nephrology, Dialysis, Transplantation, vol. 30, no. 4, pp. 564–574, 2015. View at Google Scholar
  62. Y. Cho, D. W. Johnson, D. A. Vesey et al., “Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients,” BMC Nephrology, vol. 15, article 8, 2014. View at Publisher · View at Google Scholar · View at Scopus
  63. D. Lopes Barreto, A. M. Coester, M. Noordzij et al., “Variability of effluent cancer antigen 125 and interleukin-6 determination in peritoneal dialysis patients,” Nephrology, Dialysis, Transplantation, vol. 26, pp. 3739–3744, 2011. View at Google Scholar
  64. N. Kosaka, H. Iguchi, and T. Ochiya, “Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis,” Cancer Science, vol. 101, no. 10, pp. 2087–2092, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. Y. Liang, D. Ridzon, L. Wong, and C. Chen, “Characterization of microRNA expression profiles in normal human tissues,” BMC Genomics, vol. 8, article 166, 2007. View at Publisher · View at Google Scholar · View at Scopus
  66. J. M. Lorenzen, R. Kumarswamy, S. Dangwal, and T. Thum, “microRNAs in diabetes and diabetes-associated complications,” RNA Biology, vol. 9, no. 6, pp. 820–827, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. K. M. Akat, D. Moore-McGriff, P. Morozov et al., “Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 30, pp. 11151–11156, 2014. View at Publisher · View at Google Scholar · View at Scopus
  68. G. Di Leva, M. Garofalo, and C. M. Croce, “MicroRNAs in cancer,” Annual Review of Pathology, vol. 9, pp. 287–314, 2014. View at Publisher · View at Google Scholar · View at Scopus