Research Article
G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population
Table 4
Genotypes distribution of VKORC1 C1173T polymorphism in patients with IS and control subjects with different risk factors.
| | Group | | Genotype | | | C/C (%) (95% CI) | C/T (%) (95% CI) | T/T (%) (95% CI) |
| | Total |
| | IS | 170 | 63 (37.1) (29.8–44.3) | 74 (43.5) (36.1–51.0) | 33 (19.4) (13.5–25.4) | 0.178 | | Control | 124 | 59 (47.6) (38.8–56.4) | 47 (37.9) (29.4–46.4) | 18 (14.5) (8.3–20.7) |
| | Gender |
| | Women | | | | | | | IS | 72 | 24 (33.3) (22.4–44.2) | 32 (44.4) (33.0–56.0) | 16 (22.2) (12.6–31.8) | 0.154 | | Control | 45 | 22 (48.9) (34.3–63.5) | 18 (40.0) (25.7–54.3) | 5 (11.1) (1.9–20.3) |
| | Men | | | | | | | IS | 98 | 39 (39.8) (30.1–49.5) | 42 (42.9) (33.1–52.7) | 17 (17.3) (9.9–24.9) | 0.626 | | Control | 79 | 37 (46.8) (35.8–57.8) | 29 (36.7) (26.1–47.3) | 13 (16.5) (8.3–24.6) |
| | BMI |
| | BMI < 25 kg/m2 | | | | | | | IS | 41 | 16 (39.0) (24.1–54.0) | 16 (39.0) (24.1–54.0) | 9 (22.0) (9.3–34.6) | 0.568 | | Control | 38 | 19 (50.0) (34.1–65.9) | 11 (28.9) (14.5–43.4) | 8 (21.1) (8.1–34.0) |
| | BMI ≥ 25 kg/m2 | | | | | | | IS | 129 | 47 (36.4) (28.1–44.8) | 58 (45.0) (36.4–53.6) | 24 (18.6) (11.9–25.3) | 0.212 | | Control | 85 | 40 (47.1) (36.5–57.7) | 35 (41.2) (30.7–51.6) | 10 (11.8) (4.9–18.6) |
| | Arterial blood pressure |
| | Nonhypertensive | | | | | | | IS | 42 | 16 (38.1) (23.4–52.8) | 19 (45.2) (30.2–60.3) | 7 (16.7) (5.4–27.9) | 0.725 | | Control | 48 | 22 (45.8) (31.7–59.9) | 18 (37.5) (23.8–51.2) | 8 (16.7) (6.1–27.2) |
| | Hypertensive | | | | | | | IS | 128 | 47 (36.7) (28.4–45.1) | 55 (43.0) (34.4–51.5) | 26 (20.3) (13.3–27.3) | 0.140 | | Control | 73 | 37 (50.7) (39.2–62.2) | 26 (35.6) (24.6–46.6) | 10 (13.7) (5.8–21.6) |
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See Table 2.
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