G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population

Table 5

Analysis of C1173T genotypic association with IS under four common models of inheritance.

Model		(95% CI)		(95% CI)	AIC
Total
Dominant	0.071	1.542 (0.963–2.467)	0.054	1.914 (0.989–3.449)	18.96
Recessive	0.275	1.418 (0.757–2.657)	0.701	1.165 (0.535–2.538)	21.00
Overdominant	0.333	1.263 (0.787–2.026)	0.055	1.811 (0.989–3.318)	21.28
Additive	0.135	1.475 (0.886–2.455)	0.078	2.058 (0.912–3.926)	20.76
	0.117	1.717 (0.874–3.373)	0.260	1.620 (0.700–3.749)
Gender
Women
Dominant	0.096	1.913 (0.892–4.102)	0.109	2.115 (0.846–5.286)	16.83
Recessive	0.135	2.286 (0.774–6.751)	0.243	2.162 (0.593–7.879)	17.17
Overdominant	0.637	1.200 (0.563–2.556)	0.454	1.427 (0.563–3.617)	19.41
Additive	0.242	1.630 (0.720–3.690)	0.217	1.869 (0.692–5.046)	17.79
	0.069	2.933 (0.921–9.347)	0.131	2.886 (0.730–11.413)
Men
Dominant	0.347	1.333 (0.732–2.426)	0.165	1.744 (0.796–3.823)	17.38
Recessive	0.875	1.066 (0.483–2.352)	0.794	0.872 (0.311–2.444)	18.24
Overdominant	0.407	1.293 (0.704–2.375)	0.101	1.998 (0.874–4.569)	17.58
Additive	0.340	1.374 (0.715–2.640)	0.099	2.091 (0.871–5.018)	19.33
	0.619	1.241 (0.530–2.905)	0.756	1.192 (0.394–3.602)
BMI
BMI < 25 kg/m^2
Dominant	0.328	1.562 (0.639–3.818)	0.496	1.476 (0.481–4.527)	15.23
Recessive	0.923	1.055 (0.360–3.089)	0.536	0.637 (0.153–2.655)	16.18
Overdominant	0.347	1.571 (0.613–4.025)	0.208	2.213 (0.642–7.626)	15.30
Additive	0.292	1.727 (0.626–4.769)	0.260	2.112 (0.575–7.763)	17.06
	0.625	1.336 (0.418–4.268)	0.820	0.839 (0.184–3.830)
BMI ≥ 25 kg/m^2
Dominant	0.122	1.551 (0.889–2.706)	0.053	2.142 (0.974–4.310)	18.40
Recessive	0.184	1.714 (0.774–3.796)	0.346	1.598 (0.603–4.236)	18.94
Overdominant	0.585	1.167 (0.671–2.031)	0.141	1.683 (0.842–3.367)	20.50
Additive	0.257	1.410 (0.778–2.556)	0.054	2.085 (0.989–4.397)	19.65
	0.099	2.043 (0.873–4.777)	0.118	2.322 (0.806–6.868)
Arterial blood pressure
Nonhypertensive
Dominant	0.459	1.375 (0.592–3.194)	0.295	1.730 (0.620–4.828)	15.44
Recessive	1.000	1.000 (0.329–3.038)	0.628	0.701 (0.166–2.955)	15.99
Overdominant	0.457	1.377 (0.593–3.199)	0.157	2.167 (0.743–6.318)	15.43
Additive	0.423	1.451 (0.584–3.610)	0.181	2.157 (0.700–6.648)	17.34
	0.763	1.203 (0.362–4.001)	0.978	0.978 (0.209–4.584)
Hypertensive
Dominant	0.055	1.771 (0.989–3.173)	0.071	1.960 (0.944–4.066)	17.64
Recessive	0.242	1.606 (0.726–3.553)	0.362	1.571 (0.594–4.152)	19.93
Overdominant	0.307	1.362 (0.753–2.465)	0.246	1.558 (0.736–3.299)	20.31
Additive	0.115	1.665 (0.883–3.142)	0.116	1.901 (0.853–4.236)	19.42
	0.097	2.047 (0.877–4.775)	0.164	2.097 (0.740–5.946)

See Table 3.