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BioMed Research International
Volume 2016 (2016), Article ID 3938523, 8 pages
http://dx.doi.org/10.1155/2016/3938523
Research Article

Comparison of Neuroprotective Effect of Bevacizumab and Sildenafil following Induction of Stroke in a Mouse Model

1Department of Neurosurgery, Rabin Medical Center-Beilinson Hospital, 49100 Petach Tikva, Israel
2Krieger Eye Research Laboratory, Felsenstein Medical Research Center, 49202 Petach Tikva, Israel
3Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel
4Pediatric Ophthalmology Unit, Schneider Children’s Medical Center of Israel, 49100 Petach Tikva, Israel

Received 9 January 2016; Revised 11 April 2016; Accepted 21 April 2016

Academic Editor: Monica Fedele

Copyright © 2016 Ivan Novitzky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Sun, K. Jin, L. Xie et al., “VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia,” The Journal of Clinical Investigation, vol. 111, no. 12, pp. 1843–1851, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. H. Strickler and H. I. Hurwitz, “Bevacizumab-based therapies in the first-line treatment of metastatic colorectal cancer,” The Oncologist, vol. 17, no. 4, pp. 513–524, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. S. J. Peak and V. A. Levin, “Role of bevacizumab therapy in the management of glioblastoma,” Cancer Management and Research, vol. 2, no. 1, pp. 97–104, 2010. View at Google Scholar · View at Scopus
  4. J. M. Pitlick, K. F. Vecera, K. N. Barnes, J. W. Reski, and A. B. Forinash, “Bevacizumab for the treatment of neovascular age-related macular degeneration,” Annals of Pharmacotherapy, vol. 46, no. 2, pp. 290–296, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. J. A. Wells, A. R. Glassman, A. R. Ayala et al., “Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema,” The New England Journal of Medicine, vol. 372, no. 13, pp. 1193–1203, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. Grivas, D. T. Trafalis, and A. E. Athanassiou, “Implication of bevacizumab in fatal arterial thromboembolic incidents,” Journal of B.U.ON., vol. 14, no. 1, pp. 115–117, 2009. View at Google Scholar · View at Scopus
  7. T. J. Fraum, T. N. Kreisl, J. Sul, H. A. Fine, and F. M. Iwamoto, “Ischemic stroke and intracranial hemorrhage in glioma patients on antiangiogenic therapy,” Journal of Neuro-Oncology, vol. 105, no. 2, pp. 281–289, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. D. Corbin, “Mechanisms of action of PDE5 inhibition in erectile dysfunction,” International Journal of Impotence Research, vol. 16, supplement 1, pp. S4–S7, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. C. F. Barnett and R. F. Machado, “Sildenafil in the treatment of pulmonary hypertension,” Vascular Health and Risk Management, vol. 2, no. 4, pp. 411–422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Pache, P. Meyer, C. Prünte, S. Orgül, I. Nuttli, and J. Flammer, “Sildenafil induces retinal vasodilatation in healthy subjects,” The British Journal of Ophthalmology, vol. 86, no. 2, pp. 156–158, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. M. A. S. Fernandes, R. J. F. Marques, J. A. F. Vicente et al., “Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H2O2 generation by rat heart mitochondria,” Molecular and Cellular Biochemistry, vol. 309, no. 1-2, pp. 77–85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Wang, P. W. Fisher, L. Xi, and R. C. Kukreja, “Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection,” Journal of Molecular and Cellular Cardiology, vol. 44, no. 1, pp. 105–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. R. M. Whitaker, L. P. Wills, L. J. Stallons, and R. G. Schnellmann, “CGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury,” The Journal of Pharmacology and Experimental Therapeutics, vol. 347, no. 3, pp. 626–634, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Raposo, A. K. D. S. Nunes, R. L. D. A. Luna, S. M. D. R. Araújo, M. A. da Cruz-Höfling, and C. A. Peixoto, “Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS/NO system in an inflammatory demyelination model,” Mediators of Inflammation, vol. 2013, Article ID 321460, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Charriaut-Marlangue, T. Nguyen, P. Bonnin et al., “Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia,” Stroke, vol. 45, no. 3, pp. 850–856, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Lorberboym, I. Mena, J. Wainstein, M. Boaz, and Y. Lampl, “The effect of sildenafil citrate (Viagra) on cerebral blood flow in patients with cerebrovascular risk factors,” Acta Neurologica Scandinavica, vol. 121, no. 6, pp. 370–376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Engel, S. Kolodziej, U. Dirnagl, and V. Prinz, “Modeling stroke in mice—middle cerebral artery occlusion with the filament model,” Journal of Visualized Experiments, no. 47, article 2423, 2011. View at Google Scholar · View at Scopus
  18. D. Rappoport, D. Morzaev, S. Weiss et al., “Effect of intravitreal injection of bevacizumab on optic nerve head leakage and retinal ganglion cell survival in a mouse model of optic nerve crush,” Investigative Ophthalmology & Visual Science, vol. 54, no. 13, pp. 8160–8171, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. D. Nicholson, A. C. Puche, Y. Guo, D. Weinreich, B. J. Slater, and S. L. Bernstein, “PGJ2 provides prolonged CNS stroke protection by reducing white matter edema,” PLoS ONE, vol. 7, no. 12, Article ID e50021, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Pushkov, J. D. Nicholson, S. Michowiz et al., “Relative neuroprotective effects hyperbaric oxygen treatment and TLR4 knockout in a mouse model of temporary middle cerebral artery occlusion,” International Journal of Neuroscience, vol. 126, no. 2, pp. 174–181, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Morzaev, J. D. Nicholson, T. Caspi, S. Weiss, E. Hochhauser, and N. Goldenberg-Cohen, “Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice,” Clinical and Experimental Ophthalmology, vol. 43, no. 7, pp. 655–665, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. C. R. Mackay, “Moving targets: cell migration inhibitors as new anti-inflammatory therapies,” Nature Immunology, vol. 9, no. 9, pp. 988–998, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. L. T. Watts, R. Lloyd, R. J. Garling, and T. Duong, “Stroke neuroprotection: targeting mitochondria,” Brain Sciences, vol. 3, no. 2, pp. 540–560, 2013. View at Publisher · View at Google Scholar
  24. Y. Dong, F. Song, J. Ma et al., “Small-animal PET demonstrates brain metabolic change after using bevacizumab in a rat model of cerebral ischemic injury,” Neuroscience Bulletin, vol. 30, no. 5, pp. 838–844, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. X.-M. Chen, N.-N. Wang, T.-Y. Zhang, F. Wang, C.-F. Wu, and J.-Y. Yang, “Neuroprotection by sildenafil: neuronal networks potentiation in acute experimental stroke,” CNS Neuroscience and Therapeutics, vol. 20, no. 1, pp. 40–49, 2014. View at Publisher · View at Google Scholar · View at Scopus