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BioMed Research International
Volume 2016 (2016), Article ID 5237827, 5 pages
http://dx.doi.org/10.1155/2016/5237827
Research Article

The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma

1School of Life Sciences, Fudan University, Shanghai 200433, China
2School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
3Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received 4 November 2015; Accepted 28 March 2016

Academic Editor: Xin-yuan Guan

Copyright © 2016 Xiao-Chen Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The interrelationship among genetic variations between the developing process of carcinoma and the order of occurrence has not been completely understood. Interpreting the mechanisms of copy number variation (CNV) is absolutely necessary for understanding the etiology of genetic disorders. Oncogenetic tree is a special phylogenetic tree inferential pictorial representation of oncogenesis. In our present study, we constructed oncogenetic tree to imitate the occurrence of genetic and cytogenetic alterations in human breast cancer. The oncogenetic tree model was built on CNV of ErbB2, AKT2, KRAS, PIK3CA, PTEN, and CCND1 genes in 963 cases of tumors with sequencing and CNA data of human breast cancer from TCGA. Results from the oncogenetic tree model indicate that ErbB2 copy number variation is the frequent early event of human breast cancer. The oncogenetic tree model based on the phylogenetic tree is a type of mathematical model that may eventually provide a better way to understand the process of oncogenesis.