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BioMed Research International
Volume 2016, Article ID 5469371, 9 pages
Research Article

Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse

1College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
2Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, China
3Inner Mongolia Prataculture Research Center, Chinese Academy of Science, Hohhot 010031, China
4State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
5Department of Biology, Indiana State University, Terre Haute, IN 47809, USA
6The Center for Genomic Advocacy, Indiana State University, Terre Haute, IN 47809, USA

Received 11 April 2016; Revised 15 July 2016; Accepted 27 July 2016

Academic Editor: Nicola Cirillo

Copyright © 2016 Jianghong Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genetic networks provide new mechanistic insights into the diversity of species morphology. In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice. We found that the gene expression network in the skin is highly divergent between human and mouse. The GO term of secretion was highly enriched, and this category was specific in human compared to mouse. These secretion genes might be involved in eccrine system evolution in human. In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs. The interactions between miRNAs and IGs in human are more complex than those in mouse. Furthermore, hsa-miR-548, mmu-miR-466, and mmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response. The pattern of distribution on the chromosome of these three miRNAs families is very different. The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin. Our results are generating new insights into the gene networks basis of skin difference between human and mouse.