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BioMed Research International
Volume 2016, Article ID 5469371, 9 pages
Research Article

Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse

1College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
2Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, China
3Inner Mongolia Prataculture Research Center, Chinese Academy of Science, Hohhot 010031, China
4State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
5Department of Biology, Indiana State University, Terre Haute, IN 47809, USA
6The Center for Genomic Advocacy, Indiana State University, Terre Haute, IN 47809, USA

Received 11 April 2016; Revised 15 July 2016; Accepted 27 July 2016

Academic Editor: Nicola Cirillo

Copyright © 2016 Jianghong Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: A summarizes this entire methodology. 1627 of these genes are related with the integument phenotype (MP:0010771). The expression data of 1487 IGs of mouse and human were downloaded from the Gene Expression Omnibus (GEO). MicroRNAs (miRNAs) that potential regulate IGs were predicted by miRanda, miRTarBase and miRDB. The regulation network of miRNAs-IGs and IGs-IGs was integrated, and the networks were visualized in Cytoscape. Figure S2: Chromosome location for integument genes, left for human and right for mouse. The distribution of IGs on chromosomes for human and mouse was investigated by two R packages ( and 1627 IGs are dispersed along the chromosomes of human and mouse. Table S1: The informations of microarray data used in this paper. Table S2: The common pairs of miRNA-target gene predicted by three databases (miRanda, miRTarBase and miRDB).

  1. Supplementary Material