Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function

Table 1

Summary of GPIIb (ITGA2B) variations detected in this study.

Sequence number obtained in this study	dbSNP	Location	NC_000017.11	NM_000419.3	Nucleotide change	NP_000410.2 amino acid change	MA(F)	H-W
ITGA2B-01	rs3760364	5′ upstream end	44390436	-963	ctcccaaggg A/T ctcatttaca		T(0.052)	0.609
ITGA2B-02	New	5′ upstream end	44390152	-679	tagaccaagg T/C ccattcacca		C(0.006)	0.957
ITGA2B-03	New	5′ upstream end	44390081	-608	caagacggag G/A aggagtgagg		A(0.006)	0.957
ITGA2B-04	New	Exon3	44385910	354	tgatgagacc C/T gaaatgtagg	Arg108Stop	T(0.006)	0.957
ITGA2B-05	New	Exon13	44380960	1344	ctcccaggtc C/A tggacagccc	Leu438Met	A(0.006)	0.957
ITGA2B-06	rs201355504	Intron13	44380821	1393+58	cttggcactt C/T cagcgaatgt		A(0.006)	0.957
ITGA2B-07	New	Exon14	44380638	1401	tagacctgat C/G gtgggagctt	Ile467Met	G(0.006)	0.957
ITGA2B-08	rs850730	Intron21	44377095	2188-7C>G	ccctcctcat C/G tcccagatag		G(0.477)	0.289
ITGA2B-09	New	Exon23	44376336	2320	cgtgccggtc C/T gggcagaggc	Arg774Trp	T(0.006)	0.957
ITGA2B-10	rs117870452	Exon23	44376322	2334	gcagctccac C/T tgggcctctg	Gln778=	G(0.012)	0.913
ITGA2B-11	rs5911	Exon26	44375697	2621T>G	ggggctgggg A/C tgggcagccc	Ile874Ser	G(0.477)	0.289
ITGA2B-12	rs5910	Exon30	44372421	3063C>T	acccccaggt C/T ggcttcttca	Val1021=	T(0.465)	0.289
ITGA2B-13	New	3′-UTR	44372213	151C>A	gctacccccc C/A tcctgctgcc		A(0.017)	0.869

dbSNP, single nucleotide polymorphism database; H-W , Hardy–Weinberg equilibrium value; MA(F), minor allele (frequency); GP, glycoprotein.
SNPs which related with bleeding time in this study.