Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function

Table 3

Summary of ITGB3 variations detected in this study.

Sequence number obtained in this study	dbSNP	Location	NC_000017.11	NM_000212.2	Nucleotide change	NP_000410.2 amino acid change	MA(F)	H-W
ITGB3-01	rs147363351	5′-UTR	47253042	-820	agcttccaga G/A gttttaagtc		A(0.012)	0.913
ITGB3-02	rs3809862	5′-UTR	47253062	-800	ctggggaaga C/T ccagggactc		T(0.424)	0.822
ITGB3-03	rs7208170	5′-UTR	47253393	-469	aaggcattca G/A cagatgtttg		A(0.419)	0.680
ITGB3-04	New	5′-UTR	47253360	-502	tagtgaataa T/A aaaggactga		A(0.023)	0.913
ITGB3-05	rs7208055	5′-UTR	47253461	-401	gtgaatgtgt C/A ccaagaatcc		A(0.221)	0.273
ITGB3-06	rs55827077	5′-UTR	47253717	-145	tagagaagcc G/C gaggggagga		C(0.448)	0.494
ITGB3-07	rs567581451	5′-UTR	47253771	-91	acccaccgcg -/TCCCC tcccctcccc		insTCCCC(0.058)	0.567
ITGB3-08	rs117052258	5′-UTR	47253855	-7	cgcgggaggc G/C gacgagatgc		C(0.227)	0.771
ITGB3-09	New	Exon1	47253882	21	ggccgcggcc C/G cggccgctct	Pro7=	G(0.407)	0.567
ITGB3-10	rs11871251	Intron1	47254061	79+121	ctgggaatgc G/A cgtgtcctgg		A(0.453)	0.771
ITGB3-11	New	Intron1	47254082	79+152	tggcgcggt C/G ggagccggga		G(0.012)	0.913
ITGB3-12	rs112188890	Intron1	47254101	79+161	gagctgggga C/T cttcctggcc		T(0.116)	0.864
ITGB3-13	rs117414137	Intron1	47254192	79+252	aggctgagcg C/G cttcccggcc		G(0.116)	0.864
ITGB3-14	rs11871447	Intron1	47254252	79+312	ccgcgctcac C/G cggggctgcg		G(0.448)	0.918
ITGB3-15	New	Intron1	47254331	79+391	tggggcttcc G/A ggggttgttc		A(0.006)	0.957
ITGB3-16	rs1009312	Intron1	47254774	79+834	ggcacagccc G/A gggttgctgc		G(0.471)	0.000
ITGB3-17	rs2015049	Intron1	47254865	79+925	ggccgcctct G/A cctcagagga		A(0.529)	0.000
ITGB3-18	rs56197296	Intron5	47287025_47287029	778-45_778-41	catggctgaa TTTGT/- tttgtctcct		delTTTGT(0.169)	0.049
ITGB3-19	rs5919	Exon6	47287174	882	ttgtccagcc T/C aatgacgggc	Pro294=	C(0.262)	0.022
ITGB3-20	rs41504748	Intron7	47290145	1036-40	accaccagct T/C cctttggtaa		C(0.070)	0.334
ITGB3-21	rs15908	Exon9	47290971	1143	cttccagctc A/G/T actttagaac	Val381=	C(0.599)	0.006
ITGB3-22	New	Exon10	47292177	1299	gaggctgtcc C/T caggagaagg	Pro433=	T(0.006)	0.957
ITGB3-23	rs4642	Exon10	47292411	1533A>G	cagcaggacga A/G tgcagccccc	Glu511=	G(0.331)	0.214
ITGB3-24	rs13306487	Exon10	47292422	1544	tgcagccccc A/C/G ggagggtcag	Arg515Gln	A(0.012)	0.913
ITGB3-25	rs4634	Exon10	47292423	1545	gcagcccccg G/A gagggtcagc	Arg515=	A(0.331)	0.214
ITGB3-26	New	Exon10	47292528	1659	gcgagtgtga C/Tgacttctcct	Asp550=	T(0.006)	0.957
ITGB3-27	rs149823724	Exon11	47299519	1902	cagatgcctg C/T acctttaaga	Cys634=	T(0.006)	0.957
ITGB3-28	rs11870252	Intron11	47300459	1914-19	ccttaatcac T/C gtgtcctctc		C(0.035)	0.869
ITGB3-29	rs70940817	Exon12	47300524	1960	cctacatgac G/A aaaatacctg	Glu654Lys	A(0.076)	0.432

dbSNP, single nucleotide polymorphism database; H-W , Hardy–Weinberg equilibrium value; MA(F), minor allele (frequency).
SNPs which related with ADP induced platelets aggregation, GPIIb/IIIa content, bleeding time, or coagulation indexes in this study.