Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function
Table 4
Association between individual ITGA2B and ITGB3 SNPs and the ADP induced platelets aggregation, GPIIb/IIIa content, bleeding time, PLT, and MPV (mean ± SD).
dbSNP
Genotypes
Aggregation max
GPIIb-IIIa per platelet
Bleeding time (s)
PLT (109/L)
MPV (fL)
rs3760364
AA
48
AT
7
0.148
0.433
0.038
0.512
0.911
rs7208170
GG
18
GA
24
AA
13
0.229
0.105
0.030
0.428
0.051
rs55827077
GG
18
GC
22
CC
14
0.091
0.021
0.401
0.251
0.141
rs567581451
-/-
49
-/insTCCCC
6
0.609
0.999
0.040
0.428
0.054
rs117052258
GG
29
GC
21
CC
4
0.165
0.539
0.028
0.764
0.288
GG
19
GA
22
AA
14
0.189
0.160
0.027
0.944
0.029
rs56197296
TTTGT/TTTGT
42
TTTGT/del
11
del/del
2
0.014
0.916
0.695
0.433
0.416
rs5919
TT
31
TC
16
CC
8
0.015
0.634
0.130
0.728
0.148
Note: Pearson’s two-tailed test was used to analyze correlation between genotype and parameter. rs1009312 was completely linked with rs2015049.
