Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Table 7

Risk of developing DCM/AF for each genotype at loci identified as significantly associated with DCM/AF.

Genotype	Risk	Total genotype	Risk relative to population risk	95% CI
Chr1 CC	0.81	54	1.08	0.91 to 1.28
Chr1 CT	0.68	22	na	na
Chr1 TT	0.5	4	na	na
Chr1 CT/TT	0.65	26	0.86	0.64 to 1.17
Chr21 AA	0.61	18	0.81	0.55 to 1.19
Chr21 GA	0.77	39	na	na
Chr21 GG	0.82	33	na	na
Chr21 GA/GG	0.79	72	1.04	0.89 to 1.23
Chr37 AA	0.85	27	1.12	0.93 to 1.36
Chr37 GA	0.70	23	na	na
Chr37 GG	0.73	44	na	na
Chr37 GA/GG	0.72	67	0.95	0.78 to 1.14

The risk of developing disease for each genotype, the total number of individuals with each genotype, the relative risk of each genotype compared to the population risk, and associated 95% confidence intervals. Where dominant or recessive modes of penetrance were established or less than 5 total individuals had a genotype, genotypes were pooled and these are also presented. Chr1 refers to the SNP on chromosome 1, Chr21 the SNP on chromosome 21, and Chr37 the SNP on chromosome 37 as identified in Philipp et al. [23] and Table 1.