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BioMed Research International
Volume 2016 (2016), Article ID 7237053, 7 pages
Research Article

A Comprehensive Curation Shows the Dynamic Evolutionary Patterns of Prokaryotic CRISPRs

1Shenzhen Institutes of Advanced Technology and Key Lab for Health Informatics, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China
2Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China
3College of Computer Science and Technology, Jilin University, Changchun, Jilin 130012, China
4Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China

Received 24 January 2016; Revised 24 March 2016; Accepted 28 March 2016

Academic Editor: Hongwei Wang

Copyright © 2016 Guoqin Mai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The detailed information of CRISPRs and all the newly found DRs and spacers are included in the Supplementary Material. The definition structure of a CRISPR is given in the Supplementary Figure S1. The CRISPR annotations corrected by different rules were illustrated in the Supplementary Figures S2-S7. Supplementary Figures S2 and S3 illustrate the 6 cases with one new DR, and 4 cases with two new DRs, respectively. Supplementary Figure S4 describes 3 cases with partial DRs covered by long spacers. Supplementary Figures S5 and S6 illustrate 59 cases with DRs broken by transposons, 15 more cases broken by undetected internal DRs. Supplementary Figure S7 describes 8 CRISPRs broken due to that a circular microbial chromosome is recorded as a linear DNA sequence.

  1. Supplementary Material