BioMed Research International

Functional Genomics, Genetics, and Bioinformatics 2016


Status
Published

Lead Editor

1Rush University Medical Center, Chicago, USA

2University of Chicago, Chicago, USA

3National Cancer Center, Division of Molecular Modification and Cancer Biology, Tokyo, Japan

4Ningbo University, Ningbo, China

5Johns Hopkins University, Baltimore, USA

6Indiana State University, Terre Haute, USA


Functional Genomics, Genetics, and Bioinformatics 2016

Description

Biology has become the land of the “-omics,” including genomics, transcriptomics, proteomics, lipidomics, and metabolomics. Each of these “-omics” generates a huge amount of high-throughput data, and it is a challenge both to analyze these data and to further investigate the function of specific molecules. Though more genomes have been completed due to the rapid development of sequencing technology, we cannot understand the information contained within a genome until we mine out its implicated functions. Therefore, the major challenges we meet today are not those of the traditional approach but instead fall under the task of functional annotation of genomes, which includes dynamic aspects such as gene identification, gene transcription, translation, modification, and protein-protein interactions using bioinformatic tools and high-throughput methods. In addition, the genetic information implicated in a genome sequence is critical for understanding the relationship between the genome and its expressed traits. Some diseases are reported as being caused by genetic disorders, such as changes or mutations of DNA, which can be inherited from parents; for example, Edward syndrome is caused by the anomalous presence of three copies of chromosome 18 in each cell. In contrast to such genetic causes, epigenetic ones are thought of as changes of gene expression without changes of DNA sequence, and epigenetic alternation may be caused by environment or other postnatal factors. Most diseases such as colorectal cancer are caused by both accumulated alternations of genetic and epigenetic factors, so faster and more accurate methods are urgently needed for next-generation sequence data analysis. In this special issue, we would focus on functional “-omics” and bioinformatics.

The special issue will provide a platform to integrate the most recent development and ideas in the field.

Potential topics include, but are not limited to:

  • Translational bioinformatics, focusing more on using bioinformatics methods to analyze “-omics” data
  • Functional study of specific molecular and pathway analysis
  • Computational systems biology
  • Bioinformatics algorithm and tool development: any new tools, methods, and their evaluation for “-omics” data analysis
  • Medical and health informatics by using “-omics” data
  • Integrative data analysis
  • Genome annotation and comparative genomics
  • Traditional bioinformatics

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 2625831
  • - Editorial

Functional Genomics, Genetics, and Bioinformatics 2016

Youping Deng | Hongwei Wang | ... | Yongsheng Bai
  • Special Issue
  • - Volume 2016
  • - Article ID 8329513
  • - Research Article

Functions of thga1 Gene in Trichoderma harzianum Based on Transcriptome Analysis

Qing Sun | Xiliang Jiang | ... | Mei Li
  • Special Issue
  • - Volume 2016
  • - Article ID 1648030
  • - Research Article

Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells

Kailian Xu | Shiyu Guo | ... | Fengyang Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 8642703
  • - Research Article

Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

Petr Ponomarenko | Dmitry Rasskazov | ... | Nikolay Kolchanov
  • Special Issue
  • - Volume 2016
  • - Article ID 9480276
  • - Research Article

QuaBingo: A Prediction System for Protein Quaternary Structure Attributes Using Block Composition

Chi-Hua Tung | Chi-Wei Chen | ... | Yen-Wei Chu
  • Special Issue
  • - Volume 2016
  • - Article ID 7863706
  • - Research Article

Reconstruction of the Fatty Acid Biosynthetic Pathway of Exiguobacterium antarcticum B7 Based on Genomic and Bibliomic Data

Regiane Kawasaki | Rafael A. Baraúna | ... | Maria P. C. Schneider
  • Special Issue
  • - Volume 2016
  • - Article ID 1687623
  • - Research Article

Social Determinants of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Related Lifestyle and Behaviors among Urban Men in China: A Case-Control Study

Yan Wang | Chen Chen | ... | Huarong Ye
  • Special Issue
  • - Volume 2016
  • - Article ID 8479587
  • - Research Article

A Shortest Dependency Path Based Convolutional Neural Network for Protein-Protein Relation Extraction

Lei Hua | Chanqin Quan
  • Special Issue
  • - Volume 2016
  • - Article ID 9140541
  • - Research Article

Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson’s Disease Cell Model

Li Jinfeng | Wang Yunliang | ... | Cao Bingzhen
  • Special Issue
  • - Volume 2016
  • - Article ID 9142190
  • - Research Article

Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach

Md. Abu Saleh | Md. Solayman | ... | Siew Hua Gan
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
 Submit