Human Endogenous Retroviruses-K (HML-2) Expression Is Correlated with Prognosis and Progress of Hepatocellular Carcinoma

Table 2

Prognostic factors in Cox proportional hazards model.

Factors		⁢Univariate analysis		⁢Multivariate analysis
		HR (95% CI)		HR (95% CI)
Gender	84	1.542 (0.549–4.327)	0.411
Age	80	0.911 (0.492–1.685)	0.766
Smoking	83	1.266 (0.689–2.326)	0.448
Alcoholism	83	1.097 (0.561–2.142)	0.787
Cirrhosis	48	0.813 (0.362–1.826)	0.616
Tumor number	80	0.546 (0.194–1.535)	0.251
ALT	80	0.978 (0.528–1.812)	0.944
AST	80	1.013 (0.551–1.861)	0.967
AFP	76	1.463 (0.786–2.723)	0.230
Differentiation	74	1.866 (0.903–3.853)	0.092
TNM (III~IV versus I~II)	76	4.386 (2.009–9.575)	<0.001	3.660 (1.647–8.130)	0.001
HERV-K expression (high low versus low high)	84	3.017 (1.563–5.820)	0.001	2.121 (1.070–4.203)	0.031

was considered statistically significant; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AFP: α-fetoprotein; TNM: tumor-node-metastasis.