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BioMed Research International
Volume 2017, Article ID 2748340, 17 pages
Review Article

Biophysical Mechanisms Mediating Fibrin Fiber Lysis

Department of Physics, East Carolina University, N304 Howell Science Complex, Greenville, NC 27858, USA

Correspondence should be addressed to Nathan E. Hudson; ude.uce@61nnosduh

Received 3 February 2017; Accepted 30 April 2017; Published 28 May 2017

Academic Editor: Robert A. S. Ariens

Copyright © 2017 Nathan E. Hudson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical parameters on lytic rates of fibrin fibers. The influences of fiber and network architecture, fiber strain, FXIIIa cross-linking, and particle transport phenomena will be assessed. The importance of the mechanical aspects of fibrinolysis is emphasized, and future research avenues are discussed.