Parental Genetic Variants, MTHFR 677C>T and MTRR 66A>G, Associated Differently with Fetal Congenital Heart Defect

Table 4

Allele distribution differences of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms in either mothers or fathers between control and CHD (VSD and non-VSD).

Genes	Alleles	Parent	Non-VSD (78) versus control (114)				VSD (21) versus control (114)
			χ^2	P	OR	95% CI	χ^2	P	OR	95% CI
MTHFR 677C>T	T versus C	Mother	9.654	0.002	1.930	1.272–2.928	0.290	0.590	0.833	0.429–1.619
		Father	5.973	0.015	1.669	1.105–2.521	0.595	0.441	0.769	0.394–1.501
MTHFR 1298A>C	C versus A	Mother	0.365	0.546	1.209	0.653–2.235	0.916	0.339	1.554	0.626–3.854
		Father	0.174	0.677	1.128	0.641–1.984	0.001	0.975	0.985	0.385–2.520
MTRR66 A>G	G versus A	Mother	3.298	0.069	1.535	0.965–2.442	6.539	0.011	2.421	1.213–4.833
		Father	0.382	0.537	1.166	0.716–1.898	5.696	0.017	2.308	1.147–4.645

Note: for exact number of each allele see Table 3.