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BioMed Research International
Volume 2017 (2017), Article ID 3098230, 6 pages
https://doi.org/10.1155/2017/3098230
Review Article

Nanomedicine for Inner Ear Diseases: A Review of Recent In Vivo Studies

Department of Otolaryngology-Head and Neck Surgery, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea

Correspondence should be addressed to Dong-Kee Kim

Received 18 July 2017; Accepted 30 August 2017; Published 10 October 2017

Academic Editor: Kenneth H. Lee

Copyright © 2017 Dong-Kee Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review in vivo animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid) (PLGA). The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss.