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BioMed Research International
Volume 2017, Article ID 3258681, 11 pages
Review Article

Current Status and Future Perspective of Stenting for Symptomatic Intracranial Atherosclerotic Disease: A Meta-Analysis

1Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
2Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China
3Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
4Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China

Correspondence should be addressed to Zun-Jing Liu; moc.361@gnijnuzuil

Received 24 February 2017; Revised 10 April 2017; Accepted 7 May 2017; Published 18 June 2017

Academic Editor: Sheng Chen

Copyright © 2017 Zhong-Hao Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the safety and effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) for intracranial atherosclerotic disease (ICAD) by conducting a meta-analysis. Two independent observers searched PubMed, EMBASE, and Cochrane Library for relevant studies up to 31 December 2016. A meta-analysis was conducted using Review Manager 5.3. Three studies involving 581 cases were included. The meta-analysis indicated that any stroke (RR = 3.13; 95% CI: 1.80–5.42), ischemic stroke (RR = 2.15; 95% CI: 1.19–3.89), and intracranial hemorrhage (RR = 14.71; 95% CI: 1.96–110.48) within 30 days in medical therapy alone were lower compared with PTAS plus medical therapy, but there were no significant differences in any stroke and ischemic stroke beyond 30 days between the two groups. There were also no significant differences in any death and myocardial infarction between the two groups. This meta-analysis demonstrated that, compared with medical therapy alone, PTAS for ICAD had a high risk of complication, but most complications in PTAS group occurred within 30 days after the operation, and beyond 30 days the PTAS was not inferior compared with medical therapy alone. Further studies are needed to reduce the periprocedural complications and reappraise the PTAS.