Molecular Abnormalities Underlying Bone Fragility in Chronic Kidney Disease

Figure 1

Possible factors involved in bone fragility. Both mineral metabolism disorders and uremic condition induce bone fragility. The detailed mechanisms and interactions are described in the text. Gray-shaded boxes indicate the phenomena induced by mineral metabolism disorders. Detailed descriptions of components of bone quality are shown in Table 1. Pi, phosphorus; Ca, calcium; FGF23, fibroblast growth factor 23; conc, concentration.